zymostenol

RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88

Also Known As:

5alpha-cholest-8(9)-en-3beta-ol; 8(9)-cholestenol; delta(8)-cholestenol; zymostenol, (3beta)-isomer

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Poirot, Marc: 1 article (01/2018)
2.	Silvente-Poirot, Sandrine: 1 article (01/2018)
3.	Hartman, Rachael D: 1 article (11/2010)
4.	Molho-Pessach, Vered: 1 article (11/2010)
5.	Schaffer, Julie V: 1 article (11/2010)
6.	Bröcker, Eva-Bettina: 1 article (01/2008)
7.	Grzeschik, Karl-Heinz: 1 article (01/2008)
8.	Haas, Dorothea: 1 article (01/2008)
9.	Hamm, Henning: 1 article (01/2008)
10.	Kolb-Mäurer, Annette: 1 article (01/2008)

1.	Chondrodysplasia Punctata (Stippled Epiphyses) 11/15/2010 - "An elevated plasma 8(9)-cholestenol level confirmed the diagnosis of Conradi-Hünermann-Happle syndrome, which is caused by mutations in the emopamil binding protein (EBP) gene. " 01/01/2008 - "Diagnosis of Conradi-Hünermann-Happle syndrome was confirmed by plasma sterol analysis showing markedly elevated levels of 8(9)-cholestenol and 8-dehydrocholesterol and by detection of a missense mutation (c.307G>A; p.E103K) in the emopamil-binding protein gene. "
2.	Neoplasms (Cancer) 01/01/2018 - "The induction of lethal autophagy by DDA was associated with the accumulation in cancer cells of lysosomes and of the pro-lysosomal cholesterol precursor zymostenol due to the inhibition of the 3β-hydroxysteroid-Δ8Δ7-isomerase enzyme (D8D7I). "
3.	COVID-19 10/20/2023 - "The concentrations of zymosterol, 24-dehydrolathosterol, desmosterol, and zymostenol were significantly altered in COVID-19 patients. "
4.	Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects 02/14/2000 - "Because CDPX2 patients have abnormal 8-dehydrosterol metabolism caused by mutations in 3beta-hydroxysteroid-delta8,delta7-isomerase, we measured plasma sterols in a patient with CHILD syndrome and found levels of 8-dehydrocholesterol and 8(9)-cholestenol increased to the same degree as in CDPX2 patients. "

1.	Sterols
2.	Carrier Proteins (Binding Protein)
3.	emopamil (levemopamil)
4.	cholesta-5,8-dien-3 beta-ol
5.	Isomerases
6.	Enzymes
7.	Desmosterol
8.	Cholesterol
9.	zymosterol
10.	bis(p-chlorophenyl)acetic acid (DDA)