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crisnatol
structure given in first source
Also Known As:
2-(6-(chrysenylmethyl)amino)-2-methyl-1,3-propanediol; BW A 770U; BWA770U; BWA770U mesylate; 1,3-Propanediol, 2-((6-chrysenylmethyl)amino)-2-methyl-
Networked:
8
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
Chrysenes
crisnatol: 8
Alcohols: 595
Glycols: 38
Propylene Glycols: 2
crisnatol: 8
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
Chrysenes
crisnatol: 8
Related Diseases
1.
Neoplasms (Cancer)
11/01/1992 - "
One of a novel series of compounds (AMAPS or arylmethylaminopropanediols), 773U82-HCl has shown significant antitumor activity in in vitro and in in vivo tumor systems, but has less animal CNS toxicity than the lead compound in the same series (crisnatol).
"
11/01/1999 - "
This Phase I and pharmacological study was performed to assess the feasibility of administering the polycyclic aromatic hydrocarbon crisnatol in increasingly prolonged continuous i.v. infusions to patients with advanced solid malignancies.
"
11/01/1999 - "
A phase I and pharmacological study of protracted infusions of crisnatol mesylate in patients with solid malignancies.
"
12/01/1989 - "
In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator.
"
10/01/1989 - "
MELC exposed to the cancer chemotherapeutic agents adriamycin, m-AMSA, or crisnatol (Burroughs Wellcome 770U82) also exhibit increased cellular CF fluorescence.
"
2.
Carcinoma (Carcinomatosis)
07/01/1992 - "
A phase II study of crisnatol mesylate in patients with ovarian carcinoma.
"
3.
Disease Progression
01/01/1997 - "
Two other patients remained stable on crisnatol for 10 months before disease progression.
"
4.
Ovarian Neoplasms (Ovarian Cancer)
07/01/1992 - "
Fourteen patients with advanced ovarian cancer received a 72 hour infusion of a new DNA intercalator, crisnatol mesylate, administered intravenously.
"
5.
Oligodendroglioma
01/01/1997 - "
One patient with mixed oligodendroglioma/glioblastoma progressed after 12 months on crisnatol.
"
Related Drugs and Biologics
1.
Mesylates (Mesylate)
2.
Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)
3.
Intercalating Agents
4.
DNA (Deoxyribonucleic Acid)
5.
Antineoplastic Agents (Antineoplastics)
6.
A-Form DNA (A-DNA)
7.
Doxorubicin (Adriamycin)
8.
Amsacrine (AMSA)