|1.||Tomasz, Maria: 2 articles (02/2005 - 10/2002)|
|2.||Tomasz, M: 2 articles (09/2001 - 06/2001)|
|3.||Palom, Y: 2 articles (09/2001 - 06/2001)|
|4.||Caldwell, Gary W: 1 article (08/2005)|
|5.||Lang, Wensheng: 1 article (08/2005)|
|6.||Masucci, John A: 1 article (08/2005)|
|7.||Clement, Cristina C: 1 article (02/2005)|
|8.||Ramos, Leilani A: 1 article (02/2005)|
|9.||Basu, Ashis K: 1 article (02/2005)|
|10.||Das, Arunangshu: 1 article (02/2005)|
02/01/2005 - "2,7-Diaminomitosene (2,7-DAM) is the major metabolite of MC in tumor cells, generated by the reduction of MC. "
10/25/2002 - "The various DNA adducts formed upon treatment of mouse mammary tumor cells with MC as well as 10-decarbamoyl MC (DMC) and 2,7-diaminomitosene (2,7-DAM), the major MC metabolite, have been elucidated. "
09/04/2001 - "2,7-Diaminomitosene (2,7-DAM), the major metabolite of the antitumor antibiotic mitomycin C, forms DNA adducts in tumor cells. "
01/01/1998 - "Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C."
06/15/2001 - "The six DNA adducts formed in EMT6 mouse mammary tumor cells upon treatment with mitomycin C (MC) fall into two groups: (1) four guanine adducts of MC and (2) two guanine adducts derived from 2,7-diaminomitosene (2,7-DAM), the major reductive metabolite of MC. "
01/01/1995 - "The progress of mitomycin C (MMC) bioreduction was studied in vivo in the rat Sp 107 mammary carcinoma after intra-tumoural injection of either 100 micrograms or 1 mg. 2,7-Diaminomitosene (2,7-DM) was utilised as a primary bioreductive metabolite and 10-decarbamoyl 2,7-diaminomitosene (DC 2,7-DM) served as a secondary bioreductive metabolite, both of which were measured by high-performance liquid chromatography. "
08/15/2005 - "The MC metabolite profiles were confirmed using purified human cytochrome P450 reductase, acidic activation, and UV-Vis detection at 550 nm. In hypoxia, MC was exclusively metabolized into 2,7-diaminomitosene-10-glutathione-S-conjugate (2,7-DAM-10-SG) within 30 min, whereas approximately 5% of this conjugate, 16% of 2,7-diaminomitosene (2,7-DAM), and 77% of MC were observed under a fully aerobic condition at 90 min. Under limitedly aerobic conditions, the relative percentages of the two metabolites in incubations varied greatly depending on the volume ratio of air to liquid. "
|3.||NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
|5.||DNA (Deoxyribonucleic Acid)