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N-(3-phenoxycinnamyl)acetohydroxamic acid
Also Known As:
BW A4C; BW-A4C; BW4C; BWA 4C; BWA-4C
Networked:
7
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Hydroxylamines: 16
Hydroxamic Acids: 239
N-(3-phenoxycinnamyl)acetohydroxamic acid: 7
Amides: 2428
Acetamides: 21
Benzeneacetamides
N-(3-phenoxycinnamyl)acetohydroxamic acid: 7
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzeneacetamides
N-(3-phenoxycinnamyl)acetohydroxamic acid: 7
Carboxylic Acids: 973
Hydroxy Acids: 94
Hydroxamic Acids: 239
N-(3-phenoxycinnamyl)acetohydroxamic acid: 7
Related Diseases
1.
Anaphylaxis (Anaphylactic Shock)
06/01/1988 - "
6. The results of the present study are consistent with BW A4C, BW A137C and BW A797C attenuating 'leukotriene-dependent' bronchial anaphylaxis in anaesthetized guinea-pigs by selective inhibition of arachidonate 5-lipoxygenase.
"
2.
Eosinophilia
01/01/1991 - "
BW 755C (25 mg/kg) and the more selective lipoxygenase inhibitor BW A4C (20 micrograms/cavity) suppressed the pleural eosinophilia induced by bradykinin (50 micrograms/cavity), whereas the platelet-activating factor (PAF)-acether antagonist BN 52021 was inactive.
"
06/01/1993 - "
Pretreatment with indomethacin, BW 755C (a dual cyclo/lipoxygenase inhibitor), BW A4C (a specific lipoxygenase inhibitor) or the platelet activating factor (PAF) antagonists WEB 2086 and PCA 4248 failed to inhibit the endotoxin-induced pleural eosinophilia, whilst dexamethasone (5-10 micrograms/cavity) or cycloheximide (14-28 micrograms/cavity) abolished this phenomenon.
"
3.
Ventricular Tachycardia
11/01/1997 - "
3. BW A4C (1 and 0.3 microM) did not prevent the onset of ventricular fibrillation and ventricular tachycardia despite a slight delay in the occurrence of ventricular fibrillation and cardiac arrest at the 0.3 microM concentration.
"
4.
Ventricular Fibrillation
11/01/1997 - "
3. BW A4C (1 and 0.3 microM) did not prevent the onset of ventricular fibrillation and ventricular tachycardia despite a slight delay in the occurrence of ventricular fibrillation and cardiac arrest at the 0.3 microM concentration.
"
5.
Uveitis
01/01/1994 - "
Various classes of anti-inflammatory compounds like steroids (dexamethasone), cyclooxygenase inhibitors (indomethacin and flurbiprofen), 5-lipoxygenase inhibitors (BWA 218C and BWA 4C), immunosuppressive drugs (cyclosporin and rapamycin) and cod liver oil were tested for their antiinflammatory activities in endotoxin-induced uveitis model in rabbits.
"
Related Drugs and Biologics
1.
N- (3- (5,6,7,8- tetrahydro- 2- naphthyl)prop- 2- enyl)acetohydroxamic acid
2.
Leukotrienes
3.
Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
4.
N-(4-benzyloxybenzyl)acetohydroxamic acid
5.
Lipoxygenase Inhibitors
6.
4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
7.
Platelet Activating Factor
8.
Indomethacin (Indometacin)
9.
Endotoxins
10.
Dexamethasone (Maxidex)