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N-(3-phenoxycinnamyl)acetohydroxamic acid

Also Known As:

BW A4C; BW-A4C; BW4C; BWA 4C; BWA-4C

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Related Diseases

1.	Anaphylaxis (Anaphylactic Shock) 06/01/1988 - "6. The results of the present study are consistent with BW A4C, BW A137C and BW A797C attenuating 'leukotriene-dependent' bronchial anaphylaxis in anaesthetized guinea-pigs by selective inhibition of arachidonate 5-lipoxygenase."
2.	Eosinophilia 01/01/1991 - "BW 755C (25 mg/kg) and the more selective lipoxygenase inhibitor BW A4C (20 micrograms/cavity) suppressed the pleural eosinophilia induced by bradykinin (50 micrograms/cavity), whereas the platelet-activating factor (PAF)-acether antagonist BN 52021 was inactive. " 06/01/1993 - "Pretreatment with indomethacin, BW 755C (a dual cyclo/lipoxygenase inhibitor), BW A4C (a specific lipoxygenase inhibitor) or the platelet activating factor (PAF) antagonists WEB 2086 and PCA 4248 failed to inhibit the endotoxin-induced pleural eosinophilia, whilst dexamethasone (5-10 micrograms/cavity) or cycloheximide (14-28 micrograms/cavity) abolished this phenomenon. "
3.	Ventricular Tachycardia 11/01/1997 - "3. BW A4C (1 and 0.3 microM) did not prevent the onset of ventricular fibrillation and ventricular tachycardia despite a slight delay in the occurrence of ventricular fibrillation and cardiac arrest at the 0.3 microM concentration. "
4.	Ventricular Fibrillation 11/01/1997 - "3. BW A4C (1 and 0.3 microM) did not prevent the onset of ventricular fibrillation and ventricular tachycardia despite a slight delay in the occurrence of ventricular fibrillation and cardiac arrest at the 0.3 microM concentration. "
5.	Uveitis 01/01/1994 - "Various classes of anti-inflammatory compounds like steroids (dexamethasone), cyclooxygenase inhibitors (indomethacin and flurbiprofen), 5-lipoxygenase inhibitors (BWA 218C and BWA 4C), immunosuppressive drugs (cyclosporin and rapamycin) and cod liver oil were tested for their antiinflammatory activities in endotoxin-induced uveitis model in rabbits. "

Related Drugs and Biologics

1.	N- (3- (5,6,7,8- tetrahydro- 2- naphthyl)prop- 2- enyl)acetohydroxamic acid
2.	Leukotrienes
3.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
4.	N-(4-benzyloxybenzyl)acetohydroxamic acid
5.	Lipoxygenase Inhibitors
6.	4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
7.	Platelet Activating Factor
8.	Indomethacin (Indometacin)
9.	Endotoxins
10.	Dexamethasone (Maxidex)