01/01/1994 - "A new oral triazole antifungal, SCH 39304, was administered to 54 patients with progressive infections due to Coccidioides immitis from six collaborating centers. "
01/01/1993 - "Sch 39304 is a new broad spectrum triazole antifungal agent that is active, orally and topically, against superficial Trichophyton mentagrophytes and vaginal Candida albicans infections. "
01/01/1993 - "Sch 39304, a new antifungal agent: oral and topical treatment of vaginal and superficial infections."
02/01/1992 - "albicans vaginal infection in hamsters, SCH 42427 p.o. "
02/01/1992 - "In a pulmonary Aspergillus flavus infection in mice, SCH 42427 p.o. "
|2.||Body Weight (Weight, Body)
09/01/1991 - "Optimum protection was obtained when a single dose of 10 mg of AMB per kg of body weight was combined with a fairly narrow SCH 39304 dose range. "
06/01/1990 - "We characterized the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). "
04/01/1991 - "Only SCH 39304 at 25 or 50 mg/kg of body weight per day produced 100% survival for 30 days after the 20-day treatment, although only 33% of the mice were cleared of infection. "
05/01/1990 - "A dose response protective effect was observed with SCH 39304 at 5 to 100 mg/kg of body weight per day, with 5 mg of SCH 39304 per kg per day providing activity similar to that of 100 mg of fluconazole per kg per day. "
06/01/1990 - "The 50% effective dose for SM-8668 was assessed at 10 days after infection and was 0.18, 3.7, and 5.9 mg/kg (body weight), respectively, for the above-mentioned fungal diseases. "
08/01/1990 - "SCH-39304 also was most effective in granulocytopenic rabbits with disseminated candidiasis when used for prevention or early treatment."
08/01/1990 - "Thus, SCH-39304 was comparable to treatment control regimens in prevention and early treatment of subacute disseminated candidiasis. "
08/01/1990 - "To investigate the potential use of SCH-39304 for the prevention and treatment of disseminated candidiasis in granulocytopenic patients, we studied its in vivo antifungal activity as preventive, early, and late treatments in three models (acute, subacute, and chronic) of disseminated candidiasis in persistently granulocytopenic rabbits. "
08/01/1990 - "SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits."
08/01/1991 - "Interactions of amphotericin B and SCH 39304 in the treatment of experimental murine candidiasis: lack of antagonism of a polyene-azole combination."
05/01/1990 - "We conclude that SCH 39304 is effective in murine blastomycosis treatment and deserves to be evaluated in the treatment of human blastomycosis."
04/01/1991 - "SCH 39304 was clearly superior on a milligram-per-kilogram basis in acute blastomycosis, and long-term treatment of more severe blastomycosis was curative."
04/01/1991 - "In a model of established blastomycosis, used to evaluate long-term treatment of very sick or moribund mice, SCH 39304 at 50 mg/kg/day protected against death with a 96% cumulative 8-week survival. "
04/01/1991 - "SCH 39304 in the treatment of acute or established murine pulmonary blastomycosis."
05/01/1990 - "Treatment of murine pulmonary blastomycosis with SCH 39304, a new triazole antifungal agent."
10/01/1991 - "The efficacy of SCH 39304 (SCH) against Aspergillus fumigatus was assessed with an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis. "
10/01/1991 - "Efficacy of SCH 39304 in treatment of experimental invasive aspergillosis."
11/01/1992 - "Response of trichosporonosis to azoles was seen in all eight patients, although one patient died with disseminated aspergillosis while still receiving SCH 39304. "
06/01/1990 - "The prophylactic effect of SM-8668 was excellent against systemic candidiasis, aspergillosis, and cryptococcosis in mice. "
|3.||Amphotericin B (Amphotericin)
|4.||liposomal amphotericin B
|5.||deoxycholate drug combination amphotericin B
|8.||Interferon-gamma (Interferon, gamma)
|9.||Immunoglobulin E (IgE)
|1.||Drug Therapy (Chemotherapy)