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imiquimod (Aldara)

effective against herpes simplex virus infections in animals; structure given in first source

Also Known As:

Aldara; 1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine; 3M Brand of Imiquimod; R 837; R-837; S 26308; S-26308; 1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-

Networked: 844 relevant articles (192 outcomes, 164 trials/studies) for this Drug, Comments

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 25
- 2-Ring Heterocyclic Compounds
  - Quinolines: 67
    - Aminoquinolines: 6
      - imiquimod: 844

Experts

1.	Berman, Brian: 15 articles (06/2010 - 05/2002)
2.	Stockfleth, E: 11 articles (04/2010 - 10/2000)
3.	Dummer, Reinhard: 9 articles (12/2007 - 01/2003)
4.	Owens, Mary: 9 articles (11/2006 - 09/2002)
5.	Skinner, Robert B: 9 articles (03/2006 - 07/2002)
6.	Rosen, Ted: 7 articles (05/2010 - 04/2002)
7.	Chimenti, Sergio: 7 articles (01/2009 - 03/2005)
8.	Urosevic, Mirjana: 7 articles (12/2007 - 01/2003)
9.	Schön, Michael P: 7 articles (01/2007 - 01/2002)
10.	Slade, Herbert B: 6 articles (06/2010 - 04/2002)

Related Diseases

1.	Warts (Wart) 10/01/2002 - "Published studies indicate that imiquimod results in complete clearance of warts in more than 50% of patients. " 01/01/2001 - "In three trials complete clearance of warts at the end of treatment plus no recurrence occurred in 37% of patients treated with imiquimod 5% cream and 4% of those treated with placebo. " 01/01/2001 - "In five trials with HIV-negative patients complete clearance of warts at the end of treatment occurred in 51% of patients treated with imiquimod 2% or 5% cream and 6% of placebo treated patients. " 08/01/1999 - "Preliminary results of a vehicle-controlled study showed that the rate of partial clearance of warts (defined as a reduction in baseline wart area of >50%) [38%] was significantly higher with imiquimod 5% cream than with vehicle cream; however, the rate of complete clearance was not significantly higher than with vehicle cream. " 07/01/1999 - "Post-marketing trials using imiquimod demonstrated that patients who experience complete clearance of either new or recalcitrant warts tend to remain clear for longer periods as compared to other treatment modalities. " Order ALL the reference details at left...
2.	Basal Cell Carcinoma (Rodent Ulcer) 01/01/2007 - "BACKGROUND: Imiquimod is a Toll-like receptor-7 agonist capable of inducing complete clearance of basal cell carcinoma (BCC) and other cutaneous malignancies. " 09/01/2004 - "BACKGROUND: Imiquimod is a modifier of the immune response that has been proven to be an effective treatment for basal cell carcinoma (BCC). " 06/01/2010 - "We conducted a prospective, multicenter, phase 3, open-label study to assess long-term sustained clearance of superficial basal cell carcinomas (sBCCs) treated with imiquimod cream 5%. " 06/01/2010 - "Sustained clearance of superficial basal cell carcinomas treated with imiquimod cream 5%: results of a prospective 5-year study." 08/01/2005 - "We concluded that topical 5 per cent imiquimod is an effective treatment of various subtypes of basal cell carcinoma. " Order ALL the reference details at left...
3.	Actinic Keratosis 01/01/2009 - "BACKGROUND: Imiquimod 5% cream applied twice weekly for 16 weeks is effective for treating actinic keratoses but may be limited by local side effects. " 08/01/2007 - "CONCLUSION: Imiquimod 3x/wk in one or two courses of treatment appears to be effective for the treatment of actinic keratoses on the head, providing long-term clinical benefits. " 08/01/2007 - "BACKGROUND: A shorter dosing regimen of imiquimod for the treatment of actinic keratosis may be effective, with long-term clinical benefits. " 07/01/2007 - "BACKGROUND: Imiquimod has been investigated as a safe and effective therapeutic option for the treatment of actinic keratosis (AK). " 01/01/2006 - "BACKGROUND: Imiquimod 5% cream is a topically applied immune response modifier that has been shown to give effective treatment of actinic keratosis (AK). " Order ALL the reference details at left...
4.	Condylomata Acuminata (Genital Wart) 04/01/2001 - "When 5% imiquimod cream is applied three times a week up to 16 weeks, approximately two thirds of women treated with imiquimod achieve complete clearance of genital warts, whereas only about one third of men clear completely. " 09/01/2000 - "CONCLUSION: The study demonstrated that 2% imiquimod in cream with mild non-objective side effects is safe, tolerable and significantly more effective than placebo in curing external genital warts in males." 07/01/1998 - "In conclusion, the data presented demonstrate that 2% imiquimod in cream with mild to moderate subjective side effects is significantly more effective than placebo in eliminating genital warts in women." 04/01/1998 - "Patient-applied 5% imiquimod cream is effective for the treatment of external genital warts and has a favorable safety profile." 04/01/2009 - "Imiquimod is a topically used immune response modifier effective in the treatment of genital warts caused by HPV. " Order ALL the reference details at left...
5.	Hutchinson's Melanotic Freckle (Lentigo Maligna) 10/01/2007 - "Imiquimod 5% cream appears effective in the treatment of lentigo maligna. " 02/01/2005 - "Topical treatment with imiquimod seems to be effective and safe in lentigo maligna." 10/01/2000 - "Imiquimod: a novel treatment for lentigo maligna." 11/01/2003 - "To gauge the efficacy of this therapy, we undertook a trial of topical imiquimod in 30 subjects with histologically confirmed lentigo maligna. " 04/01/2006 - "Usefulness of dermoscopy to monitor clinical efficacy of imiquimod treatment for lentigo maligna." Order ALL the reference details at left...

Related Drugs and Biologics

1.	imiquimod (Aldara)
2.	Interferons
3.	Fluorouracil (Carac)
4.	Cosmetics
5.	Podophyllotoxin (Condylox)
6.	1-phenyl-3,3-dimethyltriazene (PDT)
7.	Retinoids
8.	Cytokines
9.	DNA (Deoxyribonucleic Acid)
10.	Antigens

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Curettage
3.	Aftercare (After-Treatment)
4.	Transplantation (Transplant Recipients)
5.	Transplants (Transplant)

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