cephalomannine

RN given refers to (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*(E)),11alpha,12alpha,12aalpha,12balpha))-isomer; RN for cpd without isomeric designation not available 7/88; structure given in first source

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Xu: 1 article (01/2022)
2.	Cheng, Liang: 1 article (01/2022)
3.	Guo, Zhenghui: 1 article (01/2022)
4.	Huang, Chaoyun: 1 article (01/2022)
5.	Huang, Hao: 1 article (01/2022)
6.	Huang, Jian: 1 article (01/2022)
7.	Huang, Ming: 1 article (01/2022)
8.	Lai, Yiming: 1 article (01/2022)
9.	Ling, Yihong: 1 article (01/2022)
10.	Peng, Shengmeng: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 02/01/1993 - "We conclude that tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range." 04/01/2008 - "The quantitative changes of anti-cancer ingredients such as taxol, cephalomannine, baccatin III and 10-deacetylbaccatin III in the branches and leaves of Taxus chinensis var. mairei during one growth season were measured by HPLC. " 05/01/1988 - "In order to compare the antineoplastic activities of taxol A, taxol B, a mixture of the two (taxol A 72%) and vinblastine, a human ovarian tumor serially transplanted into 104 female athymic mice was used. "
2.	Poisoning 01/01/2012 - "Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III, cephalomannine (taxol B), and 3,5-dimethoxyphenol in body fluids by liquid chromatography-tandem mass spectrometry."
3.	Neuroblastoma 02/01/1993 - "Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines." 02/01/1993 - "The cytotoxic effects of taxol, 10-deacetyltaxol, and cephalomannine at concentrations of 0.1 mug/ml to 10.0 mug/ml for one and 24 hours exposure were determined in two human glioblastoma multiforme and two neuroblastoma cell lines using the MTT method. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "Finally, targeting UBE2S with cephalomannine inhibited proliferation and invasion in vitro, and bone metastasis of PCa in vivo. "
5.	Lymphatic Metastasis 01/01/2023 - "Finally, targeting UBE2S with cephalomannine distinctly inhibited the progression of BCa in cell lines and human BCa-derived organoids in vitro, as well as in a lymphatic metastasis model in vivo, without significant toxicity. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	baccatin III
3.	cephalomannine
4.	10-deacetylbaccatine III
5.	10-deacetyltaxol
6.	Vinblastine (Vinblastine Sulfate)
7.	Antineoplastic Agents (Antineoplastics)
8.	phloroglucinol dimethyl ether