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siguazodan
Also Known As:
2-cyano-1-methyl-3-(4-(methyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-yl)phenyl)guanidine; SK&F 94836; SK&F-94836; SKF 94836
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amidines: 14
Guanidines: 29
siguazodan: 4
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridazines: 11
siguazodan: 4
Related Diseases
1.
Heart Failure
09/01/1990 - "
2-Cyano-1-methyl 3-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)phenyl)guan idine (SK&F 94836), a new positive inotrope/vasodilator, is being evaluated for the treatment of congestive heart failure.
"
04/01/1988 - "
9. We conclude that SK&F 94836, as an orally active inotropic/vasodilator agent with a sustained duration in vivo, has potential utility in the treatment of congestive heart failure.
"
2.
Eosinophilia
10/01/1997 - "
The rise in IL-5 at 3 h was additionally attenuated by the PDE3 inhibitor, siguazodan, which failed to attenuate the eosinophilia at 24 h.
"
3.
Bronchial Spasm
07/01/1994 - "
In anesthesized, ventilated guinea pigs, the i.v. ID50S against OA-induced bronchospasm were: rolipram = 0.2 mg/kg, siguazodan > 10 mg/kg and zardaverine = 2.4 mg/kg. When administered at doses up to 7.5 mg/kg, i.v., rolipram or siguazodan were markedly less effective (i.e., < or = 50% inhibition) than zardaverine (ID50S = 2.4 and 1.7 mg/kg, respectively) at blocking exogenous histamine- or LTD4-induced bronchospasm.
"
07/01/1994 - "
In conscious guinea pigs, zardaverine (5 mg/kg, intragastrically (i.g.) or the combination of rolipram and siguazodan (5 mg/kg each) were substantially more effective than rolipram or siguazodan alone at inhibiting aerosol histamine- or LTD4-induced bronchospasm.
"
07/01/1994 - "
In guinea pigs sensitized to ovalbumin (OA), the effects of three PDE inhibitors were compared: siguazodan (PDE III selective, IC50 = 0.7 microM), rolipram (PDE IV selective, IC50 = 0.8 microM) and zardaverine (dual PDE III/IV, IC50S = 2.5 microM and 1.1 microM, respectively) against histamine-, leukotriene (LT) D4- and OA-induced bronchospasm in vitro and in vivo.
"
Related Drugs and Biologics
1.
Vasodilator Agents (Vasodilators)
2.
Phosphodiesterase 3 Inhibitors
3.
Rolipram
4.
Leukotriene D4
5.
Interleukin-5 (Interleukin 5)
6.
Leukotrienes
7.
Ovalbumin
8.
Histamine (Histamine Dihydrochloride)
9.
Aerosols
10.
zardaverine