|1.||Roman, Richard J: 45 articles (10/2015 - 01/2002)|
|2.||Falck, John R: 43 articles (10/2015 - 08/2002)|
|3.||Harder, David R: 15 articles (01/2014 - 04/2002)|
|4.||Schwartzman, Michal L: 10 articles (07/2015 - 01/2008)|
|5.||Tunctan, Bahar: 9 articles (09/2014 - 09/2008)|
|6.||Malik, Kafait U: 9 articles (09/2014 - 09/2008)|
|7.||Korkmaz, Belma: 9 articles (09/2014 - 09/2008)|
|8.||Croft, Kevin D: 9 articles (07/2014 - 07/2004)|
|9.||Miyata, Noriyuki: 9 articles (03/2009 - 04/2002)|
|10.||Garcia, Victor: 8 articles (07/2015 - 08/2012)|
11/01/2008 - "Previous studies have demonstrated that administration of HET0016 inhibits brain formation of 20-HETE and reduces brain damage in a rat model of thromboembolic stroke. "
12/01/2006 - "Recent studies have implicated 20-HETE as a vasoconstrictive mediator in hemorrhagic stroke. "
12/01/2011 - "Baseline 20-HETE levels were also associated with lesion size and functional indices within the stroke patients. "
01/01/2011 - "Inhibition of 20-HETE, or increasing EET levels by inhibiting the sEH enzyme, decreases cerebral damage following stroke. "
12/01/2008 - "These results indicate the production of 20-HETE is elevated in the cerebral vasculature of SHRSP and contributes to oxidative stress, endothelial dysfunction, and the enhanced sensitivity to ischemic stroke in this hypertensive model."
|2.||Hypertension (High Blood Pressure)
09/01/2013 - "This study demonstrated that 20-HETE is a key regulator of microvascular remodeling in hypertension; its effect is independent of blood pressure elevation and androgen levels. "
04/01/2013 - "These studies indicate that locally produced 20-HETE plays an important role in modulating the myogenic and TGF responsiveness of the Af-Art and may help explain how deficiencies in the renal formation of 20-HETE could promote the development of hypertension induced glomerular injury."
08/01/2012 - "Moreover, 20-HETE-dependent vascular dysfunction and hypertension are associated with upregulation of the renin-angiotensin system This study was undertaken to examine the contribution of renin-angiotensin system to 20-HETE actions in the vascular endothelium. "
11/01/2011 - "Studies from our laboratory and others have provided substantial evidence that 20-hydroxyeicosatetraenoic acid (20-HETE) mediates the hypertension seen in rodents treated with androgen. "
06/01/2009 - "This study provides evidence for the first time that overexpression of P450 4F2 enzyme results in higher production of 20-HETE, which promotes hypertension. "
01/01/2013 - "Studies demonstrate that lipid mediator 20-Hydroxyeicosatetraenoic acid (20-HETE) synthesis and signaling are associated with the growth of cancer cells in vitro and in vivo. "
07/01/2012 - "Liquid chromatography/mass spectrometry analysis (LC-MS/MS) was performed to measure 20-HETE formation in tumor homogenates. "
10/01/2009 - "20-HETE is required for proliferation of human renal epithelial cancer."
09/15/2014 - "Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition."
10/01/2009 - "Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth."
|4.||Septic Shock (Toxic Shock Syndrome)
09/01/2014 - "Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock."
09/01/2008 - "Endotoxic shock is a systemic inflammatory response that is associated with an increase in nitric oxide production and a decrease in the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which may contribute to the fall in blood pressure and vascular reactivity. "
01/01/2012 - "In this review, we will present an overview of our current understanding of the interactions between prostanoids, NO, and 20-HETE in sepsis, and provide a rationale for the development of synthetic 20-HETE analogs for the treatment of sepsis and septic shock."
01/01/2012 - "A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid."
07/01/2013 - "Taken together, we concluded that an increase in 20-HETE levels associated with a decrease in the production of vasodilator prostanoids and NO participates in the effect of NS-398 to prevent hypotension in the rat model of septic shock."
01/01/2005 - "Conversely, measures used to treat and/or prevent proteinuria may act to restore or increase glomerular 20-HETE levels."
04/01/2005 - "These studies indicate that upregulation of the glomerular formation of TGF-beta may contribute to the development of proteinuria and glomerular injury early in hypertension development in Dahl S rats by increasing P(alb) through inhibition of the glomerular production of 20-HETE."
10/01/2010 - "20-HETE also has renoprotective actions and opposes the effects of transforming growth factor β to promote proteinuria and renal end organ damage in hypertension. "
10/01/2009 - "Treatment of VECAD-4A2-transduced rats with HET0016, an inhibitor of 20-HETE biosynthesis, not only attenuated the increase in blood pressure (P < 0.05) but also improved vascular function (acetylcholine-induced relaxations) and reduced plasma creatinine and proteinuria. "
05/01/2010 - "Inhibition in TGR of 20-HETE formation combined with enhanced bioavailability of EETs attenuated the development of hypertension, cardiac hypertrophy, proteinuria, glomerular hypertrophy and sclerosis as well as renal tubulointerstitial injury. "
|1.||N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide
|2.||Alkane 1-Monooxygenase (Alkane 1 Monooxygenase)
|4.||Nitric Oxide (Nitrogen Monoxide)
|8.||Acetylcholine (Acetylcholine Chloride)
|9.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|1.||Surgical Instruments (Clip)