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3'- azido- 3'- deoxy- 5'- O- beta- glucopyranuronosylthymidine

major metabolite of zidovudine

Also Known As:

AZT glucuronide; AZT-5'-glucuronide; GAZT; zidovudine glucuronide

Networked: 10 relevant articles (4 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ambati, Jayakrishna: 1 article (01/2020)
2.	Ambati, Kameshwari: 1 article (01/2020)
3.	Ambati, Meenakshi: 1 article (01/2020)
4.	Ambati, Vidya L: 1 article (01/2020)
5.	Apicella, Ivana: 1 article (01/2020)
6.	Baker, Kirstie L: 1 article (01/2020)
7.	Gelfand, Bradley D: 1 article (01/2020)
8.	Marion, Kenneth M: 1 article (01/2020)
9.	Narendran, Siddharth: 1 article (01/2020)
10.	Pereira, Felipe: 1 article (01/2020)

Related Diseases

1.	Choroidal Neovascularization 01/01/2020 - "The aim of this study was to evaluate the efficacy of 5'-glucuronyl azidothymidine (GAZT), an antiretrovirally inert hepatic clinical metabolite of AZT, in mouse models of retinal pigment epithelium (RPE) degeneration and choroidal neovascularization (CNV), hallmark features of dry and wet age-related macular degeneration (AMD), respectively. "
2.	Macular Degeneration (Age-Related Maculopathy) 01/01/2020 - "The aim of this study was to evaluate the efficacy of 5'-glucuronyl azidothymidine (GAZT), an antiretrovirally inert hepatic clinical metabolite of AZT, in mouse models of retinal pigment epithelium (RPE) degeneration and choroidal neovascularization (CNV), hallmark features of dry and wet age-related macular degeneration (AMD), respectively. "
3.	Infections 08/01/2000 - "Semen and serum pharmacokinetics of zidovudine and zidovudine-glucuronide in men with HIV-1 infection." 07/01/1998 - "Zidovudine (3'-azido-3'-deoxythymidine [AZT]), an antiviral nucleoside analog effective in the treatment of human immunodeficiency virus infection, is primarily metabolized to an inactive glucuronide form, GAZT, via uridine-5'-diphospho-glucuronosyltransferase (UGT) enzymes. "
4.	Fibrosis (Cirrhosis) 11/01/1998 - "Therefore, we compared the pharmacokinetics of AZT and its glucuronidated metabolite (glucuronylazidothymidine [GAZT]) in HIV/HCV-coinfected hemophiliacs without cirrhosis to HIV-infected patients without chronic hepatitis. " 06/01/1990 - "The reason for such a decrease in oral clearance of zidovudine was the reduction in the GAZT formation clearance (236 +/- 73 versus 1540 +/- 540 ml/min); this led to a decrease in the AUC ratio of GAZT and zidovudine (1.3 +/- 0.6 versus 4.6 +/- 0.7), which was directly related to the severity of the cirrhosis. "
5.	Hepatitis C 11/01/1998 - "Yet despite normal oral clearance of AZT and GAZT, the increase of half-life and mean residence time of GAZT indicates a prolonged hepatic release of GAZT into the circulation of HIV-infected hemophiliacs with noncirrhotic hepatitis C."

Related Drugs and Biologics

1.	Zidovudine (Retrovir)
2.	Glucuronides
3.	Nucleosides
4.	Enzymes
5.	Antiviral Agents (Antivirals)
6.	Thymidine
7.	Probenecid (Benemid)
8.	Ether (Diethyl Ether)
9.	3'-aminothymidine