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atrial natriuretic factor prohormone (1-98)

the 98-amino acid fragment at the N-terminal of the ANP prohormone, ATRIAL NATRIURETIC FACTOR (1-126); its circulating level is related to heart diseases.
Also Known As:
ANF (1-98); ANF (Asn1-Arg98); ANP (1-98); atrial natriuretic factor (1-98); atrial natriuretic factor precursor (1-98); atriopeptin (1-98); pro-ANF (1-98); pro-ANF(1-98)
Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1. Myocardial Infarction
11/01/1993 - "These results suggest that determination of plasma N-terminal pro-atrial natriuretic factor (1-98) in the subacute phase of myocardial infarction may provide clinically relevant prognostic information that is superior to that obtained from atrial natriuretic factor (99-126) measurements and clinical evaluation."
11/01/1993 - "Prognostic significance of N-terminal pro-atrial natriuretic factor (1-98) in acute myocardial infarction: comparison with atrial natriuretic factor (99-126) and clinical evaluation."
03/01/1991 - "The measured pro ANF 1-98 and pro ANF 31-67 levels in these patients were within our normal range and significantly lower (p less than 0.001) than seen in patients with acute myocardial infarction not given thrombolytic therapy. "
11/01/1993 - "To evaluate the prognostic significance of plasma N-terminal pro-atrial natriuretic factor (1-98) concentrations measured in the subacute phase after acute myocardial infarction, and to compare the predictive value of measurement of N-terminal pro-atrial natriuretic factor (1-98) with the measurement of atrial natriuretic factor (99-126) and with clinical assessment of the degree of heart failure. "
03/01/1991 - "Seventeen patients with acute myocardial infarction, but without clinical evidence of congestive heart failure, had their circulating concentrations of the whole N-terminus (ie, pro ANF 1-98), the midportion of the N-terminus of the ANF prohormone (consisting of aa 31-67; pro ANF 31-67) and creatine phosphokinase (CPK) monitored daily for 14 days. "
2. Heart Failure
11/01/1993 - "In a multivariate model the prognostic value of N-terminal pro-atrial natriuretic factor (1-98) was better than that of atrial natriuretic factor (99-126) and clinical assessment of heart failure (N-terminal pro-atrial natriuretic factor (1-98), p = 0.0003; atrial natriuretic factor (99-126), p = 0.4513; heart failure, p = 0.0719). "
05/01/1991 - "In patients suffering from chronic renal failure ANP (1-98) was increased to 1582 +/- 196 fmol ml-1, and in dogs with congestive heart failure to 1612 +/- 244 fmol ml-1. In contrast, Cushing's syndrome dogs showed decreased N-ANP (1-98) concentrations (351 +/- 65.9 fmol ml-1). "
11/01/1993 - "To evaluate the prognostic significance of plasma N-terminal pro-atrial natriuretic factor (1-98) concentrations measured in the subacute phase after acute myocardial infarction, and to compare the predictive value of measurement of N-terminal pro-atrial natriuretic factor (1-98) with the measurement of atrial natriuretic factor (99-126) and with clinical assessment of the degree of heart failure. "
05/01/1991 - "There was a positive correlation between plasma levels of N-ANP (1-98) and C-ANP (99-126) levels (correlation coefficients: normal: r = 0.78; congestive heart failure: r = 0.76; chronic renal failure: r = 0.86; Cushing's syndrome: r = 0.57). "
05/01/1991 - "Plasma levels of the N-terminal immunoreactive peptide (N-ANP [1-98]) were measured in normal dogs, and in dogs with impaired volume regulation (congestive heart failure; chronic renal failure or Cushing's syndrome and compared with those of C-ANP (99-126). "
3. Pheochromocytoma
4. Neoplasms (Cancer)
5. Mitral Valve Insufficiency (Mitral Regurgitation)

Related Drugs and Biologics

1. Atrial Natriuretic Factor (ANF)
2. atrial natriuretic factor prohormone (31-67)
3. Thyroxine (Levothyroxine)
4. Peptides
5. Hormones
6. Guanylate Cyclase (Guanylyl Cyclase)
7. Creatine Kinase (Creatine Phosphokinase)
8. Amino Acids
9. human atrial natriuretic factor prohormone (1-30)
10. AA 31

Related Therapies and Procedures

1. Thrombolytic Therapy