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alpha-carboline

RN given refers to unlabeled cpd; structure given in first source

Also Known As:

alpha-carboline, 2H-labeled

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - alpha-carboline: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        alpha-carboline: 2
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - alpha-carboline: 2

Related Diseases

1.	Neoplasms (Cancer) 01/01/1987 - "Under conditions tested these neoplasms did not respond to alpha-carboline." 01/01/1987 - "II. Effect of alpha-carboline and its derivatives on transplantable animal neoplasms." 01/01/1986 - "It was found that of these compounds only alpha-carboline and its derivatives substituted in C-4 position with a methyl group or in 6-C position with a methyl group and fluorine or chlorine atoms caused moderate inhibition of the tumor growth of Sarcoma 180. "
2.	Sarcoma 180 01/01/1986 - "alpha-Carboline and its several derivatives have been synthesized and evaluated for their antitumor activity against L1210 lymphoid leukemia, P388 lymphocytic leukemia and Sarcoma 180. " 01/01/1986 - "The introduction of bromide, iodide atoms, hydroxy-, amino-groups or some other substituents in C-6 position of alpha-carboline molecule reduced significantly the biological activity of the tested compounds against Sarcoma 180. " 01/01/1986 - "It was found that of these compounds only alpha-carboline and its derivatives substituted in C-4 position with a methyl group or in 6-C position with a methyl group and fluorine or chlorine atoms caused moderate inhibition of the tumor growth of Sarcoma 180. "
3.	Lymphoid Leukemia 01/01/1986 - "alpha-Carboline and its several derivatives have been synthesized and evaluated for their antitumor activity against L1210 lymphoid leukemia, P388 lymphocytic leukemia and Sarcoma 180. "

Related Drugs and Biologics

1.	Iodides
2.	Fluorine
3.	Chlorine
4.	Bromides