|1.||Laporte, Jocelyn: 4 articles (04/2013 - 09/2002)|
|2.||Tooze, Sharon A: 2 articles (07/2014 - 03/2013)|
|3.||Manifava, Maria: 2 articles (09/2013 - 11/2008)|
|4.||Ktistakis, Nicholas T: 2 articles (09/2013 - 11/2008)|
|5.||Payrastre, Bernard: 2 articles (04/2013 - 11/2006)|
|6.||Stenmark, Harald: 2 articles (01/2011 - 12/2010)|
|7.||Mandel, Jean-Louis: 2 articles (11/2006 - 09/2002)|
|8.||Tronchère, Hélène: 2 articles (11/2006 - 09/2002)|
|9.||Proikas-Cezanne, Tassula: 1 article (01/2015)|
|10.||Dönnes, Pierre: 1 article (01/2015)|
|1.||Congenital Structural Myopathies (Centronuclear Myopathy)
09/01/2003 - "In families in which myotubular myopathy segregates, detected mutations in MTM1 abolish the specific phosphatase activity targeting the second messenger phosphatidylinositol 3-phosphate. "
06/01/2014 - "Myotubular myopathy is a prototypical disorder of phosphoinositide dysregulation that is characterized by profound muscle pathology and weakness and that is caused by mutations in MTM1, which encodes a phosphatase that targets 3-position phosphoinositides, including phosphatidylinositol 3-phosphate. "
11/01/2006 - "A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy."
09/22/2000 - "Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway."
04/15/2013 - "In this study, we identified myotubularin (MTM1), a phosphoinositide phosphatase mutated in X-linked centronuclear myopathy (XLCNM, or myotubular myopathy), as a key regulator of phosphatidylinositol 3-monophosphate (PtdIns3P) levels at the SR. MTM1 is predominantly located at the SR cisternae of the muscle triads, and Mtm1-deficient mouse muscles and myoblasts from XLCNM patients exhibit abnormal SR/ER networks. "
03/01/2013 - "Generation of PtdIns3P and recruitment of WIPI2 or ZFYVE1/DFCP1 to the phagophore following amino acid starvation was blocked by combined Ulk1/2 double knockout. "
07/01/2011 - "In contrast PtdIns3P is down regulated in the fat body of well-fed larvae but on starvation it accumulates in punctate vesicles throughout the cytoplasm and on refeeding it relocalises to vesicles at the periphery of the cell. "
05/01/2008 - "This finding will provide further important clues as to the origin of the autophagosome membrane, and how the process is regulated by starvation and PtdIns3P signals."
02/01/2002 - "Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe."
07/17/2014 - "Mammalian cell homeostasis during starvation depends on initiation of autophagy by endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns(3)P) synthesis. "
09/01/2013 - "Intracellular and extracellular phosphatidylinositol 3-phosphate produced by Phytophthora species is important for infection."
02/07/2012 - "Acute ablation of Vps34 in MEFs upon adenoviral Cre infection results in a diminishment of localized generation of phosphatidylinositol 3-phosphate and blockade of both endocytic and autophagic degradation. "
01/16/2009 - "Infection led to the conversion of LC3 to the autophagosome-associated form LC3-II, to the accumulation of LC3-containing vesicles near the parasitophorous vacuole, and to the relocalization toward the vacuole of structures labeled by the phosphatidylinositol 3-phosphate indicator YFP-2xFYVE. "
07/01/2005 - "This last step, which initiates infection, depends on the late endosomal lipid lysobisphosphatidic acid (LBPA) and its putative effector Alix/AIP1, and is regulated by phosphatidylinositol-3-phosphate (PtdIns3P) signalling via the PtdIns3P-binding protein Snx16. "
01/01/2012 - "Early infection steps were dependent on the production of phosphatidylinositol 3-phosphate (PtdIns3P) which is involved in EE maturation and multivesicular body (MVB) biogenesis and on the interconversion of PtdIns3P to phosphatidylinositol 3, 5-biphosphate (PtdIns(3,5)P(2)). "
01/15/2015 - "The PtdIns3P effector function of human WIPI proteins appears to be compromised in cancer and neurodegeneration, and WIPI genes and proteins might present novel targets for rational therapies. "
12/01/2010 - "Further elucidation of the mechanisms of tumour suppression mediated by class III PI3K and PtdIns3P will identify novel Achilles' heels of the cell's defence against tumourigenesis and will be useful in the search for prognostic and diagnostic biomarkers in cancer."
03/01/2002 - "Tumor cell engagement rapidly activated PI 3-kinase in NK cells within 5 min, as demonstrated by p85 subunit tyrosine phosphorylation and its ability to generate phosphatidylinositol 3-phosphate, PI(3)P, from PI. "
10/01/2008 - "tuberculosis inhibits phagolysosome biogenesis have been researched in detail and the maturation block at least partially depends on the manipulation of host phosphoinositide interconversions, with phosphatidylinositol 3-phosphate (PI3P) being a central target since it has been shown to be required for phagolysosome biogenesis. "
|4.||Proteins (Proteins, Gene)
|7.||P-2 (P 2)
|8.||Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)