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4-hydroxy-N-desmethyltamoxifen

metabolite of tamoxifen in human bile
Also Known As:
4-hydroxy-N-demethyltamoxifen; 4-hydroxy-N-desmethyltamoxifen, (Z)-isomer; endoxifen
Networked: 76 relevant articles (4 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Goetz, Matthew P: 10 articles (04/2015 - 12/2005)
2. Ingle, James N: 8 articles (04/2015 - 12/2005)
3. Ames, Matthew M: 6 articles (04/2015 - 12/2005)
4. Safgren, Stephanie L: 5 articles (04/2015 - 12/2005)
5. Zembutsu, Hitoshi: 5 articles (01/2015 - 05/2008)
6. Flockhart, David A: 5 articles (12/2014 - 05/2005)
7. Teft, Wendy A: 5 articles (07/2014 - 03/2011)
8. Kim, Richard B: 5 articles (07/2014 - 03/2011)
9. Spelsberg, Thomas C: 5 articles (01/2014 - 03/2009)
10. Hawse, John R: 5 articles (01/2014 - 03/2009)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Neoplasms (Cancer)
3. Hot Flashes
4. Melanoma (Melanoma, Malignant)
09/05/2013 - "Altogether, our results show for the first time that a combined treatment of all-trans-retinoic acid with endoxifen may provide an anti-proliferative and anti-migration effect upon melanoma cells without major toxicity, offering a powerful therapeutic strategy for malignant melanoma."
09/05/2013 - "Moreover, the combination of all-trans-retinoic acid with endoxifen significantly decreased melanoma cells migration, whereas the combination with tamoxifen did not present significant effects. "
09/05/2013 - "The combination of the antiestrogen endoxifen with all-trans-retinoic acid has anti-proliferative and anti-migration effects on melanoma cells without inducing significant toxicity in non-neoplasic cells."
09/05/2013 - "Thus, we investigated the effects of all-trans-retinoic acid combined with the antiestrogen endoxifen on melanoma cell proliferation and the effects were compared with its pro-drug tamoxifen. "
10/05/2015 - "On one hand, it is now believed that metabolism is a major determinant of tamoxifen clinical outcomes in breast cancer patients, which is a variable that has yet to be tested in melanoma patients, since the tamoxifen active metabolite endoxifen demonstrated superior cytostatic activity over the parent drug in melanoma cells; on the other hand, new evidence has emerged regarding estrogen-mediated signaling in melanoma cells, including the methylation of the estrogen receptor-α gene promoter and the expression of the G protein coupled estrogen receptor. "
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. Tamoxifen
2. Cytochrome P-450 CYP2D6 (CYP2D6)
3. Estrogens (Estrogen)
4. 4-hydroxytamoxifen
5. Aromatase Inhibitors
6. Cytochrome P-450 Enzyme System (Cytochrome P450)
7. Enzymes
8. N-desmethyltamoxifen
9. Culture Media
10. Hormones

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Individualized Medicine
3. Therapeutics