|1.||Jaworska-Feil, L: 2 articles (12/2010 - 01/2001)|
|2.||Budziszewska, B: 2 articles (12/2010 - 01/2001)|
|3.||Lipkowski, A W: 1 article (12/2010)|
|4.||Basta-Kaim, A: 1 article (12/2010)|
|5.||Kubera, M: 1 article (12/2010)|
|6.||Leskiewicz, M: 1 article (12/2010)|
|7.||Lason, W: 1 article (12/2010)|
|8.||Jantas, D: 1 article (12/2010)|
|9.||Pantoni, Leonardo: 1 article (11/2004)|
|10.||Sarkadi, Adám: 1 article (01/2002)|
|1.||Alzheimer Disease (Alzheimer's Disease)
08/01/1995 - "Posatirelin (L-pyro-2-aminoadipyl-L-leucil-L-prolinamide) a new synthetic tripeptide with cholinergic, catecholaminergic and neurotrophic properties, was investigated in the treatment of Alzheimer's disease. "
01/01/1998 - "In order to confirm the efficacy and safety of posatirelin (L-pyro-2-aminoadipyl-L-leucyl-L-prolinamide), a synthetic peptide having cholinergic, catecholaminergic and neurotrophic activities, a multicentre, double-blind, controlled study versus placebo was planned in elderly patients suffering from Alzheimer's disease and vascular dementia, according to National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and National Institute of Neurological Disorders and Stroke/Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN) criteria, respectively. "
08/01/1995 - "Posatirelin for the treatment of late-onset Alzheimer's disease: a double-blind multicentre study vs citicoline and ascorbic acid."
11/15/2004 - "The conclusions of the present review are that: (1) some drugs such as nicergoline, memantine, posatirelin, propentofylline, and pentoxifylline have shown some, although partly limited, benefits in VaD patients; (2) besides a lack of efficacy of the tested drugs, possible causes of the negative results of many randomized clinical trials in VaD are the enrollment of patients with heterogeneous subtypes of VaD, the small sample size, and the use of end-points and cognitive tests inadequate for the VaD setting because derived from previous experience in the field of Alzheimer disease. "
|2.||Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
06/01/1996 - "The significant improvement observed in cognitive functions, attention and motivation of demented patients treated with posatirelin suggests the potential usefulness of this drug in vascular dementia. "
01/01/1998 - "The study confirms previous results showing that treatment with posatirelin can improve cognitive and functional abilities of patients suffering from degenerative or vascular dementia."
06/01/1996 - "Posatirelin in the treatment of vascular dementia: a double-blind multicentre study vs placebo."
01/01/1998 - "Posatirelin for the treatment of degenerative and vascular dementia: results of explanatory and pragmatic efficacy analyses."
06/01/1996 - "The usefulness of posatirelin (L-pyro-2-aminoadipyl-L-leucyl-L-prolinamide), a synthetic peptide having modulatory activity on the monoaminergic and cholinergic systems and neurotrophic effects, was evaluated in vascular dementia. "
01/01/2001 - "Protective effects of TRH and its stable analogue, RGH-2202, on kainate-induced seizures and neurotoxicity in rodents."
01/01/2001 - "In conclusion, the present study showed that TRH and RGH-2202 attenuated the kainate-induced seizures and inhibited the kainate-evoked neurotoxicity in vivo and in vitro. "
01/01/2001 - "We found that TRH (2.0 and 5.0 mg/kg) and RGH-2202 (2.5 and 5 mg/kg) elevated the ED(50) for kainate-induced convulsions and tended to decrease mortality. "
09/01/1997 - "The data showed that i.v. administration of TRH (10 and 20 mg/kg), RGH-2202 (0.1 mg/kg) and Z-p-Glu-His-Pro-NH2 (10 mg/kg) increased threshold for pentetrazole-induced clonic seizures, but did not affect the tonic ones. "
01/01/2001 - "We examined the effects of TRH and its stable analogue, RGH-2202, on the kainate-induced seizures and excitotoxicity in mice - a model of a drug-resistant temporal lobe epilepsy. "
|4.||Kainic Acid (Kainate)
|8.||Cytidine Diphosphate Choline (Citicoline)
|9.||Ascorbic Acid (Vitamin C)