KW 5805

structure given in first source; RN given refers to (+)-isomer

Also Known As:

5-((2-(diethylamino)ethyl)amino)-5,11-dihydro(1)-benzoxepino(3,4-b)pyridine; KW 5805, (+-)-isomer; KW 5805, (-)-isomer; KW-5805

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Ulcer 08/01/1994 - "Effects of KW-5805, a new antiulcer agent, on various experimental ulcers, necrotizing agent-induced gastric lesions and gastric acid secretion in rats were compared with those of pirenzepine and cimetidine. "
2.	Gastric Fistula 08/01/1994 - "In rats with acute gastric fistula, intravenous injection of KW-5805 reduced methacholine-stimulated gastric acid secretion at doses of 10 and 30 mg/kg and inhibited tetragastrin-induced acid secretion at 30 mg/kg. These results indicate that KW-5805 has potent and broad antiulcer properties, which are probably exerted by its potent cytoprotective effect in addition to its antisecretory effect."
3.	Duodenal Ulcer (Curling's Ulcer) 08/01/1994 - "KW-5805 showed antiulcer activities against experimental gastric and duodenal ulcers (ED50 = 1.2-10.0 mg/kg, p.o.). " 08/01/1994 - "Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion."

1.	Methacholine Chloride (Methacholine)
2.	Tetragastrin
3.	Pirenzepine
4.	Cimetidine (Biomet)
5.	Acids

1.	Intravenous Injections