lactofen

structure given in first source

Also Known As:

1'-(carboethoxy)ethyl 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate; Benzoic acid, 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitro-, 2-ethoxy-1-methyl-2-oxoethyl ester

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenyl Ethers: 8
        Halogenated Diphenyl Ethers: 385
        lactofen: 5
- Ethers: 242
  - Phenyl Ethers: 8
    - Halogenated Diphenyl Ethers: 385
      - lactofen: 5

Experts

1.	Graham, Terrence L: 2 articles (06/2011 - 03/2003)
2.	Graham, Madge Y: 2 articles (12/2005 - 03/2003)
3.	Cross, Cory: 1 article (08/2012)
4.	Fothergill, Kent: 1 article (08/2012)
5.	Li, Shuxian: 1 article (08/2012)
6.	Rupe, John: 1 article (08/2012)
7.	Shannon, Grover: 1 article (08/2012)
8.	Shumway, Calvin: 1 article (08/2012)
9.	Wrather, Allen: 1 article (08/2012)
10.	Cheng, Jiye: 1 article (06/2011)

Related Diseases

1.	Disease Resistance 06/01/2011 - "An integrated LC-MS and NMR metabolomic study was conducted to investigate metabolites whose formation was induced by lactofen (1), a soybean (Glycine max L.) disease resistance-inducing herbicide. " 12/01/2005 - "These various results are discussed in the context of singlet oxygen-induced responses and lactofen's potential as a disease resistance-inducing agent." 03/01/2003 - "Lactofen, the active ingredient of the soybean disease resistance-inducing herbicide, Cobra, induces large accumulations of isoflavone conjugates and aglycones in soybean tissues. "
2.	Infections 08/01/2012 - "The objectives of this study were to determine the development of charcoal rot, infection of seed by Phomopsis spp., and severity of pod and stem blight on Asgrow 4403, Delta Pine 5806, United States Department of Agriculture-introduced DT 97-4290 and plant introduction (PI) number PI 567562A, and Asgrow 4403 treated and not treated with lactofen or azoxystrobin. "
3.	Wounds and Injuries (Trauma) 12/01/2005 - "Furthermore, isoflavone synthase genes, which are wound inducible in soybean, were up-regulated by lactofen in both proximal and distal cell zones in minimally wounded cotyledons and further enhanced in wounded tissues. "
4.	Neoplasms (Cancer) 03/30/1988 - "Thus, pure and technical grade lactofen appear to induce murine liver tumors through a mechanism similar to epigenetic hepatocarcinogens of the peroxisome proliferating type." 03/30/1988 - "A technical grade of lactofen (1'[carboethoxy]ethyl 5-[2-chloro-4-[trifluoro-methyl] phenoxy]-2-nitrobenzoate) has been shown to induce liver tumors in mice. "
5.	Eosinophilia 03/30/1988 - "Liver-weight to body-weight ratio, liver catalase, liver acyl-CoA oxidase, liver cell cytoplasmic eosinophilia, nuclear and cellular size, and peroxisomal staining were increased by the tumorigenic dose of lactofen, i.e., 250 ppm, in a fashion similar to the comparison chemical nafenopin (500 ppm), which is a peroxisome proliferator. "

Related Drugs and Biologics

1.	Herbicides
2.	azoxystrobin
3.	Acyl-CoA Oxidase
4.	Singlet Oxygen
5.	Selegiline (E250)
6.	Nafenopin
7.	Isoflavones
8.	Catalase
9.	isoflavone synthase