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spinacine

structure given in first source; RN from Toxlit 4/88

Also Known As:

4,5,6,7-tetrahydro-1H-imidazo(4,5-c)pyridine-6-carboxylic acid

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - spinacine: 5
  - Pyridines: 88
    - spinacine: 5

Experts

1.	Duerksen-Hughes, P J: 1 article (01/2016)
2.	Filippova, M: 1 article (01/2016)
3.	Krstenansky, J L: 1 article (01/2016)
4.	Yuan, C-H: 1 article (01/2016)
5.	Conato, Chiara: 1 article (01/2004)
6.	Kozłowski, Henryk: 1 article (01/2004)
7.	Młynarz, Piotr: 1 article (01/2004)
8.	Remelli, Maurizio: 1 article (01/2004)
9.	Silvestri, Sergio: 1 article (01/2004)
10.	Swiatek-Kozłowska, Jolanta: 1 article (01/2004)

Related Diseases

1.	Body Weight (Weight, Body) 09/01/1992 - "Acute and short term toxicological studies on spinacine enable a No Observed Effect Level of 300 mg/kg body weight/day to be determined, leading to an Acceptable Daily Intake (ADI) for man of 3 mg/kg body weight/day. " 10/01/1989 - "In this study the no-effect dose level for spinacine was considered to be 300 mg/kg body weight/day." 10/01/1989 - "Spinacine (4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid), the major reaction product of formaldehyde added to Grana Padano cheese, was administered to five groups of ten rats of each set at dietary concentrations that provided doses of O (control), 15, 30, 60 or 300 mg/kg body weight/day for 13 wk. There were no adverse effects upon survival, growth or food intake. "
2.	Tics (Tic) 10/01/1994 - "Analysis of deltorphin A position 4 analogues included: backbone constrained N (α) MeHis, spinacine (Spi), N (α) MePhe and the tetrahydroisoquinoline-3-carboxylic acid (Tic); spatially confined side-chain (Phg); and imidazole alkylation ofL- andD-His(4) enantiomers. " 01/01/2004 - "Two synthetic analogues, where the histidine residue has been substituted with L-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (L-Spinacine) and L-1,2,3,4-tetrahydro-isoquinolin-3-carboxylic acid (Tic), respectively, have been considered, as well. "
3.	Neoplasms (Cancer) 01/21/2016 - "Finally, both myricetin and spinacine sensitized HPV(+) cervical and oral cancer cells, but not HPV(-) cervical and oral cancer cells, to apoptosis induced by the cancer-specific ligand TRAIL, as well as the chemotherapeutic agents doxorubicin and cisplatin. "
4.	Mouth Neoplasms (Oral Cancer) 01/21/2016 - "Finally, both myricetin and spinacine sensitized HPV(+) cervical and oral cancer cells, but not HPV(-) cervical and oral cancer cells, to apoptosis induced by the cancer-specific ligand TRAIL, as well as the chemotherapeutic agents doxorubicin and cisplatin. "

Related Drugs and Biologics

1.	Carboxylic Acids
2.	Acids
3.	pyridine
4.	Ligands
5.	Histidine (L-Histidine)
6.	Formaldehyde (Formol)
7.	Doxorubicin (Adriamycin)
8.	Cisplatin (Platino)
9.	deltorphin
10.	myricetin