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1- (2- chloroethyl)- 1- nitroso- 3- (4- thiomorpholino)urea

structure given in first source

Also Known As:

CNTMU

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Nitrosourea Compounds: 21
      - 1-(2-chloroethyl)-1-nitroso-3-(4-thiomorpholino)urea: 1
- Nitroso Compounds: 446
  - Nitrosourea Compounds: 21
    - 1-(2-chloroethyl)-1-nitroso-3-(4-thiomorpholino)urea: 1

Related Diseases

1.

Neoplasms (Cancer)

01/01/1988 - "Additionally, CNTMU and ACNU induced a significant rise in the tumor load of the neurogenic tissue; the latter compound, being in clinical use, was associated with a significantly increased number of mammary tumors as well. "
01/01/1988 - "Long-term toxic evaluation of 1-(4-amino-2-methylpyrimidine-5-yl)-methyl-3- (2-chloroethyl)-3-nitrosoureahydrochloride (ACNU), 1-(2-chloroethyl)-1-nitroso-3-(methylene-2-pyridylium)-urea- hydrochloride (CNMPU), 1-(2-chloroethyl)-1-nitroso-3-(4-thiomorpholino)-urea (CNTMU) and 4-[N-(2-chloroethyl)-N-nitrosocarbamoyl]-morpholine (CNCM) which were administered each at five dosages, adapted to the clinical situation, revealed significantly increased tumor risks for the first three agents in the lung and the adrenal gland. "

Related Drugs and Biologics

1.	Nimustine
2.	1- (2- chloroethyl)- 1- nitroso- 3- (methylene- 2- pyridinyl)urea
3.	morpholine