probimane (AT 2153)

RN given refers to cpd without isomeric designation

Also Known As:

AT 2153; AT-2153; MM 159; MM-159; bis(4-morpholinomethyl-3,5-dioxopiperazin-1-yl)propane; bis-(4-morpholinomethyl-3,5-dioxopiperazinyl)-1-methylylethane; probimane, (+-)-isomer

Networked: 9 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - Diketopiperazines: 59
      - Razoxane: 164
        probimane: 9

Experts

1.	Lu, Da-Yong: 4 articles (01/2013 - 12/2004)
2.	Lu, Ting-Ren: 3 articles (01/2013 - 01/2010)
3.	Xu, Bin: 3 articles (01/2013 - 12/2004)
4.	Wu, Hong-Ying: 2 articles (01/2013 - 07/2010)
5.	Xu, Jing: 1 article (01/2013)
6.	Che, Jin-Yu: 1 article (07/2010)
7.	Chen, Rui-Ting: 1 article (07/2010)
8.	Qu, Rong-Xin: 1 article (07/2010)
9.	Ding, Jian: 1 article (12/2004)

Related Diseases

1.	Cardiotoxicity 01/01/1987 - "The increased solubility allowed MM-159 to be examined for protective activity against chronic doxorubicin (DXR) cardiotoxicity. " 01/01/1987 - "Such protection against DXR hematologic effects was not noted previously when dogs were pretreated with ICRF-187, the d-isomer of razoxane, despite the fact that pretreatment with ICRF-187 was as effective as MM-159 in reducing chronic DXR cardiotoxicity. " 01/01/1991 - "In order to evaluate the mechanisms of cardiotoxicity protective action of probimane, the free radical induced by doxorubicin were analysed by electron spin resonance (ESR) techniques. " 07/01/1993 - "These results suggested that protection against cardiotoxicity of doxorubicin afforded by probimane, bimolane, and dexrazoxane may be related to their ability to combine with the complex iron so that the iron was no longer able to take part in free radical reactions."
2.	Lewis Lung Carcinoma 07/01/2010 - "Probimane (Pro), as a representative of the well-known class of antimetastatic agents âBisdioxopiperazine compounds (Biz)â, is systematically studied for its absorption, distribution and excretion in mice bearing Lewis lung carcinoma by a radioactivity-detective method in this investigation. " 07/01/2010 - "Absorption, distribution and excretion of ¹⁴C-probimane in mice bearing lewis lung carcinoma." 03/01/1993 - "In the present work, 14C was labeled at central dioxopiperazine or methyl morpholine group of probimane 120 mg.kg-1 was injected iv in mice bearing Lewis lung carcinoma by whole body autoradiography. " 01/01/2013 - "The influence of antineoplastic agents (vincristine, thiotepa, adriamycin, probimane, cisplatin, oxalysine, cortisone, nitrogen mustard, lycobetaine, Ara-C, harringtonine, and cyclophosphamide) on the content of sialic acids in mice blood bearing solid tumors of either S180 or Lewis lung carcinoma was observed. "
3.	Neoplasms (Cancer) 12/24/2004 - "Probimane (Pro), an anti-cancer agent originating in China, was derived from razoxane (ICRF-159, Raz), a drug created in Britain, specifically targeting at cancer metastasis and as a cardioprotectant of anthrocyclines. " 01/01/2010 - "Novel molecular mechanisms especially relating to the inhibition of tumor metastasis between probimane and razoxane have been especially explored and explained, including pathways of inhibitions against calmodulin, sialic acid, lipoperoxidation, fibrinogen, cell-movement and the cell-cycle arrest. " 01/01/2013 - "Among these antineoplastic drugs, probimane, cisplatin, nitrogen mustard, and lycobetaine were able to decrease the serum sialic acid levels in mice bearing tumors. " 01/01/2013 - "The influence of antineoplastic agents (vincristine, thiotepa, adriamycin, probimane, cisplatin, oxalysine, cortisone, nitrogen mustard, lycobetaine, Ara-C, harringtonine, and cyclophosphamide) on the content of sialic acids in mice blood bearing solid tumors of either S180 or Lewis lung carcinoma was observed. "
4.	Neoplasm Metastasis (Metastasis) 12/24/2004 - "Probimane (Pro), an anti-cancer agent originating in China, was derived from razoxane (ICRF-159, Raz), a drug created in Britain, specifically targeting at cancer metastasis and as a cardioprotectant of anthrocyclines. " 01/01/2010 - "Novel molecular mechanisms especially relating to the inhibition of tumor metastasis between probimane and razoxane have been especially explored and explained, including pathways of inhibitions against calmodulin, sialic acid, lipoperoxidation, fibrinogen, cell-movement and the cell-cycle arrest. "
5.	Carcinoma (Carcinomatosis) 07/01/1988 - "[Effects of bimolane and probimane on the incorporation of (3H)TdR, (3H)UR and (3H)Leu into Ehrlich ascites carcinoma cells iv vitro]."

Related Drugs and Biologics

1.	Dexrazoxane (Zinecard)
2.	Doxorubicin (Adriamycin)
3.	Razoxane
4.	Free Radicals
5.	bimolane
6.	Iron
7.	N-Acetylneuraminic Acid (Sialic Acid)
8.	Vincristine (Oncovin)
9.	Thiotepa (Triethylenethiophosphoramide)
10.	Sialic Acids