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University of Wisconsin-lactobionate solution

organ preservation solution; includes lactobionate, raffinose, NaKH(2)PO(4), adenosine, MgSO(4), glutathione, allopurinol, insulin, trimethoprim/sulphamethoxazole, modified hydroxyethyl starch; polyethylene glycol replaces hydroxyethyl starch in Cardiosol
Also Known As:
Belze-UW solution; Belzer solution; Cardiosol; UW solution; University of Wisconsin cardioplegic solution; Viaspan
Networked: 167 relevant articles (12 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Du, Caigan: 3 articles (01/2017 - 03/2012)
2. Guan, Qiunong: 3 articles (01/2017 - 03/2012)
3. Akbari, Masoud: 2 articles (01/2022 - 12/2018)
4. Juriasingani, Smriti: 2 articles (01/2022 - 12/2018)
5. Sener, Alp: 2 articles (01/2022 - 12/2018)
6. Brooks, Donald E: 2 articles (01/2017 - 01/2015)
7. Chafeeva, Irina: 2 articles (01/2017 - 01/2015)
8. Kizhakkedathu, Jayachandran N: 2 articles (01/2017 - 01/2015)
9. Nguan, Christopher Y C: 2 articles (01/2015 - 03/2012)
10. Yamaya, H: 2 articles (05/2014 - 01/2005)

Related Diseases

1. Reperfusion Injury
2. Ischemia
3. Edema (Dropsy)
4. Necrosis
01/01/2013 - "We test the hypothesis that PARP inhibition can decrease acute tubular necrosis (ATN) and other renal lesions related to prolonged cold ischemia/reperfusion (IR) in kidneys preserved at 4°C in University of Wisconsin (UW) solution. "
08/01/2012 - "Cell necrosis increased significantly between TO and T1 in group 2 compared with group 1 (P < 0.05) whereas cell apoptosis was significantly higher at T1 compared with T0 in group 1 in comparison to group 2. Our results show that IGL-1 improves intestinal graft viability as compared to UW solution, possibly by reducing graft immunogenicity and by favoring intestinal epithelial repair."
01/01/1997 - "The donor's clinical status was estimated, as well as appearance, density and colour of the organ, quality of perfusion with UW solution In 23 cases the histological examination of the harvested organ allowed to estimate the degree of steatosis, hepatocyte necrosis, vacuolar degeneration and other abnormalities. "
03/15/1995 - "Significantly more tissue swelling was noted in group 3 over control, but the magnitude was less than that of group 2. Less transmural necrosis and villous blunting were noted in group 3 versus group 2; the appearance of the mucosa in group 3 approached that of group 1. We conclude that the use of U74389G treatment in addition to cold storage in UW solution improves recovery of graft function and minimizes morphologic damage to the small intestinal mucosa."
01/01/2008 - "Histologically, at 4 h after transplantation, the liver grafts preserved in UW solution demonstrated a greater degree of injury than those in ET-K, which appeared to be apoptosis, rather than necrosis. "
5. Delayed Graft Function

Related Drugs and Biologics

1. Solutions
2. Euro-Collins' solution
3. Antioxidants
4. IGL-1 solution
5. Endothelin A Receptor
6. Caspases
7. Lipids
8. Enzymes
9. DNA (Deoxyribonucleic Acid)
10. 3- (methylamino)- 2- ((methylamino)methyl)propane- 1- thiol

Related Therapies and Procedures

1. Transplantation
2. Liver Transplantation
3. Pancreas Transplantation
4. Organ Transplantation
5. Rewarming