sphingomyelin phosphodiesterase D

12/27/2022 - "The role of PLDs in cutaneous loxoscelism was described over forty years ago, when studies identified and purified toxins featured as sphingomyelinase D. "
12/01/2019 - "Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism."
11/01/2023 - "Sphingomyelinase D is a toxin present in venomous spiders and bacteria and is associated with infection symptoms in patients affected by spider bites. "
01/01/2021 - "Sphingomyelinase D in the brown recluse spider venom is unique to Loxosceles and Sicarius and may be responsible for the unique clinical presentation of loxoscelism. "
06/01/2009 - "Sphingomyelinase D (SMase D) present in the venoms of Loxosceles spiders is the principal component responsible for local and systemic effects observed in the loxoscelism. "

01/01/1988 - "This toxin, which produced skin necrosis in rabbits, contained sphingomyelinase D activity. "
10/01/1984 - "A dermonecrotic factor with sphingomyelinase D activity was purified from the spider's venom sacs which produced skin necrosis when injected intradermally in rabbits. "
05/01/2005 - "Sphingomyelinase D is known to be the causative agent of necrosis and red blood cell lysis in the venom of the brown recluse spider (Loxosceles reclusa), and our assumption was that this would be the same agent in other spider venoms as well. "

01/01/2013 - "We show here, for the first time, that the Brazilian Sicarius ornatus spider contains active Sphingomyelinase D and is able to cause haemolysis and keratinocyte cell death similar to the South American Loxosceles species, harmful effects that are associated with the presence of active SMases D. "
07/01/2011 - "Functional characterization of Heminecrolysin indicated a sphingomyelinase D, a complement-dependent hemolysis properties and a dermonecrosis activity. "
09/01/2002 - "We have recently shown that sphingomyelinase D toxins from the spider Loxosceles intermedia induce Complement (C) -dependent haemolysis of autologous erythrocytes by the induction of cleavage of cell-surface glycophorins through activation of a membrane-bound metalloproteinase. "

06/01/2013 - "We have previously identified Heminecrolysin, a sphingomyelinase D (SMaseD), as the major protein responsible for the main pathological effects observed following Hemiscorpius (H.) lepturus scorpion envenomation. "

05/01/2006 - "These injuries mostly are due to sphingomyelinase D in the spider venom. "