methoctramine

structure given in first source

Also Known As:

N,N'-bis(6-((2-methoxybenzyl)amino)hexyl)-1,8-octanediamine; N,N'-bis(6-((2-methoxybenzyl)amino)hexyl)-1,8-octanediamine tetrahydrochloride; methoctramine free base; methoctramine hydrochloride

Networked: 30 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - methoctramine: 30

Experts

1.	Lenina, Oksana A: 1 article (01/2022)
2.	Petrov, Konstantin A: 1 article (01/2022)
3.	Andrade, Carina A F: 1 article (01/2019)
4.	Anesio, Augusto: 1 article (01/2019)
5.	Barbosa, Silas Pereira: 1 article (01/2019)
6.	Colombari, Débora S A: 1 article (01/2019)
7.	Colombari, Eduardo: 1 article (01/2019)
8.	De Luca, Laurival A: 1 article (01/2019)
9.	Menani, José V: 1 article (01/2019)
10.	de Paula, Patrícia Maria: 1 article (01/2019)

Related Diseases

1.	Bradycardia 03/01/1988 - "Finally, in the pithed rat, methoctramine preferentially inhibited cardiac M2 (vagal bradycardia) over ganglionic M1 (McN-A-343-induced hypertension) responses. " 09/01/1997 - "The M2 selective antagonist methoctramine (3.16 microM) produced a 307-fold increase in the ED50 for bradycardia but had no significant effect on the pressor response to acetylcholine. " 01/01/1992 - "The muscarinic M2 antagonist, methoctramine (7-240 nmol kg-1), inhibited the bradycardia induced by both vagal stimulation and ACh (ED50: 38 +/- 5 and 38 +/- 9 nmol kg-1, respectively). " 04/01/1995 - "Using regression analysis, the dose of methoctramine necessary to prevent fentanyl-induced bradyarrhythmias without causing tachycardia was calculated as 14.4 micrograms/kg. The study confirmed that fentanyl administration in the conscious dog causes profound bradycardia with bradyarrhythmias. " 01/01/2016 - "The increased bradycardia was eliminated by hexamethonium and methoctramine (M2muscarinic receptor antagonist) but not reserpine. "
2.	Tachycardia (Tachyarrhythmias) 10/01/1997 - "Methoctramine administration caused dose-dependent tachycardia without affecting intestinal motility, while atropine administration caused dose-dependent tachycardia accompanied by significant reductions in small intestinal motility. " 04/01/1995 - "Using regression analysis, the dose of methoctramine necessary to prevent fentanyl-induced bradyarrhythmias without causing tachycardia was calculated as 14.4 micrograms/kg. The study confirmed that fentanyl administration in the conscious dog causes profound bradycardia with bradyarrhythmias. " 09/01/1988 - "Furthermore, even high doses of methoctramine (up to 1 mg/kg i.v.) did not reduce the ganglionic M1 receptor-mediated tachycardia and pressor response to muscarine or McN-A-343 in the pithed rat. " 06/01/2008 - "TC and TCCP rats exhibited a decreased response to: 1) phenylephrine-induced vagal baroreflex bradycardia; 2) methoctramine-, 4-DAMP- and tropicamide-induced tachycardia; 3) methoctramine-induced QRS shortening, and 4) tropicamide-induced QT prolongation. " 12/01/2002 - "The muscarinic blocker methoctramine blocked diving bradycardia, the alpha-adrenergic blocker prazosin blocked diving vasoconstriction, and the beta-adrenergic blocker metoprolol blocked post-dive tachycardia. "
3.	Neoplasms (Cancer) 09/01/2013 - "The ability of symmetrically substituted long chain polymethylene tetramines, methoctramine (1) and its analogs 2-4 to kill cancer cells was studied. " 09/01/2013 - "Autophagy did not protect HeLa cells against cytotoxicity elicited by compound 4. The present study shows that, by modifications of the methoctramine structure, it is possible to design polyamine derivatives highly cytotoxic against tumor cells and that the appropriate design of molecules bearing polyamine-like structures leads to powerful inducers of autophagy. " 01/01/2015 - "Our results showed that PC9 and A549 cells expressed all 5 subtypes of muscarinic receptor (mAChR) and blocking M2 mAChR (M2R) signaling using selective antagonist methoctramine or short hairpin RNA (shRNA) inhibited tumor cell proliferation in vitro and in vivo. "
4.	Neuroblastoma 09/01/1993 - "This study showed that methoctramine was toxic, in micromolar concentrations, to the human neuroblastoma cell lines SK-N-SH, LAN-5 and SH-EP1, the last being a clone that does not contain muscarinic receptors. " 09/01/1993 - "Toxicity of the specific antimuscarinic agent methoctramine and other non-specific anticholinergic drugs in human neuroblastoma cell lines in vitro."
5.	Ganglion Cysts (Ganglion) 01/01/1992 - "This ganglion blocking action of methoctramine was not due to its reported M1 receptor antagonist activity (blocking facilitatory Ml receptors in the ganglia) since pirenzepine was without effect in this preparation. " 05/01/1998 - "Both the vasopressin V1 receptor antagonist d(CH2)5-(Me)2-Tyr-AVP and the predominantly vasopressin V2 receptor antagonist d(CH2)5, D-Ile2, Ile4-AVP, the non-selective muscarinic receptor antagonist, atropine, the predominantly selective muscarinic M1 receptor antagonist, pirenzepine, the predominantly selective muscarinic M2 antagonist, methoctramine, the predominantly selective muscarinic M3 receptor antagonist, para-fluoro-hexahydro-siladifenidol, and the calcium channel blocker, nifedipine, but not the ganglion blocking agent, mecamylamine, depressed or blocked the tonic contractions induced by vasopressin. "

Related Drugs and Biologics

1.	Hexamethonium (Hexamethonium Bromide)
2.	Reserpine (Serpasil)
3.	Cholinergic Agents (Cholinergics)
4.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
5.	Cholinergic Antagonists (Anticholinergics)
6.	Polyamines
7.	Fentanyl (Sublimaze)
8.	Pirenzepine
9.	Tropicamide
10.	Muscarinic M1 Receptor