2,2- (2- chlorophenyl- 4'- chlorophenyl)- 1,1- dichloroethene

structure given in first source; metabolite of o,p-DDD (mitotane)

Also Known As:

1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)vinyl)benzene; o,p'-DDE; Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-

Networked: 13 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Mitotane: 664
        2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene: 13

Experts

1.	Berruti, Alfredo: 3 articles (11/2017 - 06/2011)
2.	Terzolo, Massimo: 3 articles (11/2017 - 06/2011)
3.	De Francia, Silvia: 2 articles (11/2017 - 02/2015)
4.	Azevedo, Lucas Silva: 1 article (05/2022)
5.	Bastos, Wanderley Rodrigues: 1 article (05/2022)
6.	Nascimento, Luiza: 1 article (05/2022)
7.	Oliveira, Ronaldo Cavalcante: 1 article (05/2022)
8.	Pestana, Inácio Abreu: 1 article (05/2022)
9.	di Beneditto, Ana Paula Madeira: 1 article (05/2022)
10.	Ha, Sam Ol: 1 article (10/2020)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2011 - "There were no non-cancer risks of DDTs and γ-HCHs on adults and children, and there were very low cancer risks of DDD, o,p'-DDE, DDT, α-HCH, β-HCH, γ-HCH based on their total concentrations in all samples. " 06/01/2011 - "Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study." 05/01/2022 - "The aim of this study was to evaluate the estimated daily intake (EDI) and the incremental lifetime cancer risk associated with Hg and o.p'DDT, p.p'DDT, o.p'DDE, and p.p'DDE in an Amazonian community. " 06/01/2011 - "The study was performed to confirm the correlation of the currently used mitotane (o,p'DDD) threshold of 14 mg/liter with tumor response and to evaluate the additional value of 1,1-(o,p'-dichlorodiphenyl) acetic acid (o,p'DDA) and o,p'DDE (1,1-(o,p'-dichlorodiphenyl)-2,2 dichloroethene) levels for predicting tumor response. "
2.	Adrenocortical Carcinoma 11/29/2022 - "It is speculated that o,p'-DDE may be an active metabolite since it has a cytotoxic effect on adrenocortical carcinoma cells (H295R). " 11/29/2022 - "Effects of o,p'-DDE, a Mitotane Metabolite, in an Adrenocortical Carcinoma Cell Line." 11/01/2017 - "Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'-DDE (dichlorodiphenylethene) and o,p'-DDA (dichlorodiphenylacetate). " 06/01/2011 - "Plasma concentrations of o,p'DDD, o,p'DDA, and o,p'DDE as predictors of tumor response to mitotane in adrenocortical carcinoma: results of a retrospective ENS@T multicenter study."
3.	Malaria 09/01/2004 - "There were no significant associations between short-to-medium-term serum DDT exposure measures (o'p'-DDE and o'p' and p'p' isomers of DDD and DDT) and malaria years. " 07/01/2012 - "We report on the concentrations of DDT and its metabolites (p,p'- DDE, p,p'-DDT, o,p'-DDE, o,p'-DDD, p,p'-DDD, and o,p'-DDT) in maternal plasma of 255 delivering women residing in three sites along Indian Ocean, namely in malaria endemic where IRS takes place, low risk and non-malaria sites. " 07/01/2012 - "Concentrations of measured compounds were found to be significantly higher in the malaria endemic site (p=0.0001): the geometric mean concentration (95% confidence intervals; n=91) for o,p'-DDE was 9 ng/g lipids (7-10); for p,p'-DDE, 3840 ng/g lipids (3008-4902); for o,p'-DDD, 8 ng/g lipids (6-9); for p,p'-DDD, 26 ng/g lipids (20-32); for o,p'-DDT, 168 ng/g lipids (127-221) and for p,p'-DDT, 2194 ng/g lipids (1706-2823). "
4.	Breast Neoplasms (Breast Cancer) 03/01/2002 - "Still, we cannot exclude a role for high level exposure to o,p'-DDE, particularly in post-menopausal ER+ breast cancer. " 02/01/2005 - "The finding that the antiestrogens tamoxifen and ICI 182,780, and an environmental estrogen, ortho,para-dichlorodiphenyldichloroethylene (o,p'-DDE), have high binding affinities to the receptor and mimic the actions of E2 has important implications for both the development and treatment of estrogen-dependent breast cancer. "
5.	Pituitary ACTH Hypersecretion 01/01/1991 - "This paper reports the results of much lower doses of o,p'-DDD (0.5-2 g per day) in two patients with Cushing's disease over periods of 8 and 5 years, respectively, under concomitant monitoring of the plasma levels of the parent drug and its major metabolite, o,p'-DDE. " 01/01/1991 - "Plasma level monitoring of mitotane (o,p'-DDD) and its metabolite (o,p'-DDE) during long-term treatment of Cushing's disease with low doses."

Related Drugs and Biologics

1.	Mitotane (Lysodren)
2.	DDT
3.	2,2- (2- chlorophenyl- 4'- chlorophenyl)acetic acid
4.	Dichlorodiphenyl Dichloroethylene (DDE)
5.	o,p'-DDT
6.	Acetic Acid (Vinegar)
7.	Dichlorodiphenyldichloroethane (DDD)
8.	Estrogen Receptor Modulators (Antiestrogen)
9.	Tamoxifen
10.	Lipids