5-ethyl-2,2'-anhydrouridine

Also Known As:

2,2'-anhydro-5-ethyluridine; 5-ethyl-O(2),2'-cyclouridine; 5-ethyl-cyclouridine; ANEUR

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Sarcoma 180 01/01/1987 - "5-Ethyl-2,2'-anhydrouridine (ANEUR) proved to be a potent inhibitor of uridine phosphorylase isolated from sarcoma 180 cells with an apparent Ki (Ki(app) value of 99 nM. Coadministration of ANEUR with 5-fluorouridine (FUR) resulted in increased toxicity of FUR. "
2.	Neoplasms (Cancer) 01/01/1987 - "When FUR was coadministered with ANEUR, mean tumor weight was 91% less than that of the untreated controls, showing that ANEUR, the potent URPase inhibitor, increases the antitumor effect of FUR." 01/01/1987 - "There was no significant difference in mean tumor weight on day 10 between control animals and animals treated with FUR (5 mg/kg/day for 3 days) or ANEUR (280 mg/kg/day for 3 days). "
3.	Hematoma 03/31/2009 - "Endovascular coil embolization can be selected at an acute stage for the treatment of aneurysms in patients with poor-grade SAH without intraparenchymal hematoma even if the aneur-ysm is large. "
4.	Colonic Neoplasms (Colon Cancer) 04/01/1990 - "2,2'-Anhydro-5-ethyluridine (ANEUR), a potent inhibitor of uridine phosphorylase, markedly potentiated the antitumor activity of fluorouridine (FUR) against murine mammary adenocarcinoma 755 in BDF1 mice and human colon adenocarcinoma LS174T in athymic-nude mice. "
5.	Aneurysm (Aneurysms) 03/31/2009 - "Endovascular coil embolization can be selected at an acute stage for the treatment of aneurysms in patients with poor-grade SAH without intraparenchymal hematoma even if the aneur-ysm is large. "