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3- (2- hydroxy- 4- (1,1- dimethylheptyl)phenyl)- 4- (3- hydroxypropyl)cyclohexanol

(-)-CP-55,940 and (+)-CP-56,667 are enantiomers; RN refers to CP-55,940
Also Known As:
CP 55940; CP 56667; CP-55,940; CP-56,667; CP55,940; CP55940
Networked: 49 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Lichtman, Aron H: 2 articles (05/2015 - 02/2011)
2. Hebbel, Robert P: 2 articles (02/2012 - 07/2010)
3. Gupta, Kalpna: 2 articles (02/2012 - 07/2010)
4. Simone, Donald A: 2 articles (02/2012 - 07/2010)
5. Deng, Chao: 2 articles (11/2007 - 07/2006)
6. Huang, Xu-Feng: 2 articles (11/2007 - 07/2006)
7. Darmani, Nissar A: 2 articles (06/2007 - 01/2003)
8. Janoyan, Jano J: 2 articles (06/2007 - 01/2003)
9. Manzanares, Jorge: 2 articles (08/2005 - 04/2003)
10. Wright, Christine E: 2 articles (03/2005 - 05/2004)

Related Diseases

1. Pain (Aches)
2. Hyperalgesia
3. Neuralgia (Stump Neuralgia)
4. Schizophrenia (Dementia Praecox)
07/01/2006 - "In the present study, we used quantitative autoradiography to investigate the binding of [(3)H]CP-55940 to CB1 receptors in the PCC in schizophrenia subjects compared to controls. "
01/01/2001 - "Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use."
01/01/2001 - "There was an increase in the density of [3H]CP-55940 binding to cannabinoid-1 receptors in the dorsolateral prefrontal cortex from subjects with schizophrenia (mean+/-S.E.M.: 142+/-9.9 vs 119+/-6.6fmol/mg estimated tissue equivalents; P<0.05) that was independent of recent cannabis ingestion. "
01/01/2001 - "To determine whether changes in the cannabinoid system were present in the brains of subjects with schizophrenia, we used in situ radioligand binding and autoradiography to measure the binding of [3H]CP-55940 to the cannabinoid-1 receptor in the dorsolateral prefrontal cortex (Brodmann's area 9), caudate-putamen and areas of the temporal lobe from schizophrenic and control subjects, some of whom had ingested cannabis close to death. "
11/01/2007 - "Contrasting to previous findings in the alterations of CB1 receptor densities in the prefrontal, anterior and posterior cingulate cortex of schizophrenia, which were suggested to be associated to impairment of cognition function, no significant difference was found between the schizophrenia and control cases in both [(3)H]SR141716A and [(3)H]CP-55940 binding. "
5. Vomiting
01/10/2003 - "CP55,940 (0.025-0.3 mg/kg) reduced both the frequency of cisplatin-induced emesis (ID(50)=0.025 mg/kg) and the percentage of shrews vomiting (ID(50)=0.09 mg/kg). "
01/10/2003 - "This study investigates the antiemetic potential of the "nonclassical" cannabinoid CP55,940 [1alpha,2beta-(R)-5alpha]-(-)-5-(1,1-dimethyl)-2-[5-hydroxy-2-(3-hydroxypropyl) cyclohexyl-phenol] against cisplatin-induced vomiting and assesses the presence and functionality of cannabinoid CB(1) receptors in the least shrew (Cryptotis parva) brain. "
06/01/2007 - "Radiation-induced emesis (10 Gy) was blocked in a dose-dependent manner by the CB1/CB2-receptor agonists with the following ID50 potency order: CP55,940 (0.11 (0.09-0.12) mg/kg)>WIN55,212,2 (3.65 (3.15-4.23) mg/kg)=Delta8-THC (4.36 (3.05-6.22) mg/kg)>Delta9-THC (6.76 (5.22-8.75) mg/kg). "
06/01/2007 - "The purpose of this study was to evaluate whether structurally-diverse cannabinoids [Delta9-THC, (delta-9-tetrahydrocannabinol); (Delta8-THC, delta-8-tetrahydrocannabinol); WIN55,212-2, (R (+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)), methyl] pyrolol [1,2,3-de]-1,4 benzoxazinyl]-(1-naphthalenyl) methenone mesylate); and CP55,940, ((-)-3-[2-hydroxy-4-(1,1-dimethylheptyl]-4-[3-hydroxypropyl] cyclohexane-1-ol)), can prevent radiation-induced emesis. "
06/01/2007 - "Cannabinoids prevented the induced emesis via the stimulation of cannabinoid CB1-receptors because the CB1 (SR141716A)--and not the CB2 (SR144528)--receptor antagonist reversed both the observed reduction in emesis frequency and shrew emesis protection afforded by either Delta9-THC or CP55,940 against radiation-induced emesis. "

Related Drugs and Biologics

1. Tetrahydrocannabinol (THC)
2. Cannabinoids
3. Cannabinoid Receptors (Cannabinoid Receptor)
4. 3- (2- hydroxy- 4- (1,1- dimethylheptyl)phenyl)- 4- (3- hydroxypropyl)cyclohexanol
5. CB2 Cannabinoid Receptor
6. Endocannabinoids (Endocannabinoid)
7. SR 144528
8. CB1 Cannabinoid Receptor (CB1 Receptor)
9. Phenol (Carbolic Acid)
10. Cisplatin (Platino)

Related Therapies and Procedures

1. Ligation
2. Catheters