bretazenil

12/01/2001 - "Bretazenil, a benzodiazepine receptor partial agonist, as an adjunct in the prophylactic treatment of OP poisoning."
12/01/2001 - "At the anticonvulsive doses (125-250 microg x kg(-1), i.p.) bretazenil, in combination with pyridostigmine (100 microg x kg(-1), i.m.) and aprophen (4 mg x kg(-1), i.m.), conferred prophylactic protection against sarin and soman poisoning (protective ratios 2.6 and 2.1, respectively). "

01/01/1995 - "Initial clinical results with bretazenil (Ro 16-6028), a partial BDZ agonist, in acute schizophrenia are, in this respect, an encouraging lead to be followed further."
07/01/1996 - "Antipsychotic effects of bretazenil, a partial benzodiazepine agonist in acute schizophrenia--a study group report."

11/01/2012 - "In contrast to the anxioselective profile displayed in preclinical models, compounds such as bretazenil, TPA023, and MRK 409 produced benzodiazepine-like side effects (sedation, dizziness) in Phase I studies, whereas alpidem and ocinaplon exhibited many of the characteristics of an anxioselective in the clinic. "

07/01/2006 - "Bretazenil was able to decrease the duration of afterdischarges as well as intensity of clonic seizures accompanying these afterdischarges in all age groups in a dose-dependent manner. "
11/01/1993 - "Based on these results, Ro 16-6028 might be predicted to be efficient against human absence seizures."
11/01/1993 - "The youngest rats exhibited maximal effects of Ro 16-6028 against major seizures. "
11/01/1993 - "Major seizures were always more sensitive to Ro 16-6028 than were minimal seizures. "
11/01/1993 - "Both types of metrazol-induced seizures, minimal (mMS, predominantly clonic with preserved righting ability) and major (MMS, generalized tonic-clonic), were suppressed by Ro 16-6028 in a dose-dependent manner. "

09/01/1999 - "Under the schedule of stimulus-shock termination, midazolam produced dose-related decreases in response rate, and these effects were surmountably antagonized by flumazenil, bretazenil, Ro 41-7812, Ro 42-8773, and beta-CCt. "
09/01/1994 - "Discontinuation of long-term treatment with diazepam or triazolam, but not of long-term treatment with imidazenil or bretazenil, sensitized rats to behavioral inhibition by punishment (electric shock) in a manner that was potentiated by flumazenil. "