garcinol

from stem bark of Garcinia huillensis; has chemotherapeutic activity against gram-positive & gram-negative cocci, mycobacteria & fungi

Also Known As:

cambogin; camboginol; bicyclo(3.3.1)(non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl))-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl-, (1R,5R,7R)-

Networked: 118 relevant articles (11 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - garcinol: 118

Experts

1.	Ho, Chi-Tang: 12 articles (01/2021 - 04/2005)
2.	Pan, Min-Hsiung: 8 articles (01/2021 - 12/2010)
3.	Sarkar, Fazlul H: 6 articles (02/2013 - 09/2009)
4.	Zhang, Hong: 5 articles (01/2020 - 07/2015)
5.	Banerjee, Sanjeev: 5 articles (02/2013 - 04/2010)
6.	Ahmad, Aamir: 5 articles (12/2012 - 09/2009)
7.	Yeh, Chi-Tai: 4 articles (03/2021 - 01/2018)
8.	Chen, Xin: 4 articles (02/2019 - 01/2012)
9.	Parasramka, Mansi A: 4 articles (01/2019 - 01/2011)
10.	Kundu, Tapas K: 4 articles (01/2016 - 01/2013)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2022 - "Since glial hyperactivation-mediated inflammation is inevitably associated with the loss of dopaminergic neurons, our study suggests the anti-inflammatory role of garcinol in facilitating dopaminergic neuroprotection in PD mice. " 03/16/2021 - "Garcinol protected cardiomyocytes by inhibiting apoptosis and inflammation in mice with AMI. " 12/01/2020 - "Taken together, the data suggest that garcinol could protect against cerebral I/R injury through attenuating inflammation and oxidative stress, and improving neurological function. " 01/01/2017 - "The association of PCAF and vascular inflammation was further investigated using the potent natural PCAF inhibitor garcinol. " 06/01/2016 - "These data indicated that the HAT inhibitor, garcinol, enhances LPS‑induced inflammation in vitro and in vivo, suggesting that acetylation modification has an important regulatory function during inflammation. "
2.	Neoplasms (Cancer) 04/15/2007 - "Garcinol was more effective in inhibiting growth of cancer cells than that of normal immortalized cells. " 03/11/2021 - "Several studies have shown anti-cancer properties of garcinol in cancer cell lines and experimental animal models. " 04/30/2020 - "Several in vitro and in vivo studies have illustrated the potential therapeutic efficiency of garcinol in management of different malignancies. " 04/30/2020 - "This review is the first effort to summarize the mechanism of action of garcinol in modulation of anti-cancer effect via regulation of different cellular processes." 04/30/2020 - "Despite various lacunae, garcinol has presented with promising anti-cancer effects. "
3.	Body Weight (Weight, Body) 03/10/2015 - "In vivo study showed that administration of garcinol alone (0.5 mg/kg body weight, i.p. " 01/01/2021 - "Dietary garcinol had no effect on average daily feed intake, body weight (BW), backfat and BW gain of late-pregnant sows. " 01/01/2019 - "The results show that garcinol reduces HFD-fed mice body weight gain and relative visceral adipose tissue fat weight in a dose-dependent manner. " 12/01/2017 - "Oral administration of garcinol (10 and 20 mg/kg body weight/day) for 30 days improved the above-mentioned alterations. "
4.	Dyskinesias (Dyskinesia) 01/01/2019 - "Garcinol serves as a potent natural HAT inhibitor and has unveiled promising results in molecular interaction studies against Monoamine oxidase B (MAO-B) and Catechol-O-Methyltransferase (COMT), as well as in L-DOPA induced dyskinesia. " 01/01/2018 - "Anacardic acid 2 mg/kg, garcinol 5 mg/kg, or curcumin 100 mg/kg co-treatment with L-DOPA significantly reduced the axial, limb, and orofacial (ALO) score indicating less dyskinesia with administration of HAT inhibitors in 6-OHDA-lesioned mice. " 01/01/2018 - "Our aim was to determine whether HAT inhibitors such as anacardic acid, garcinol, and curcumin from natural plants reduce severity of L-DOPA-induced dyskinesia using a unilaterally 6-hydroxydopamine (6-OHDA)-lesioned PD mouse model. "
5.	Neuralgia (Stump Neuralgia) 01/01/2017 - "Protective effects of Garcinol against neuropathic pain - Evidence from in vivo and in vitro studies." 01/01/2017 - "Therefore, Garcinol could be a promising agent in the treatment of neuropathic pain." 01/01/2017 - "Our findings suggest that Garcinol may have protective effects against neuropathic pain that are associated with the inhibition of neuroinflammation in microglia. " 01/01/2017 - "These findings prompted us to evaluate the protective effects of Garcinol in the lumbar fifth spinal nerve ligation (SNL)-induced rat model of neuropathic pain and Lipopolysaccharide(LPS)-stimulated primary cultured microglia. "

Related Drugs and Biologics

1.	Histones (Histone)
2.	Monoamine Oxidase (MAO)
3.	Levodopa (L Dopa)
4.	Anti-Inflammatory Agents (Anti-Inflammatories)
5.	Dimethylnitrosamine (Nitrosodimethylamine)
6.	Catechol O-Methyltransferase (Methyltransferase, Catechol)
7.	hydroxycitric acid
8.	Histone Acetyltransferases (Histone Acetyltransferase)
9.	Lipopolysaccharides
10.	Curcumin

Related Therapies and Procedures

1.	Ligation
2.	Oral Administration
3.	Radiotherapy
4.	Therapeutics
5.	Chemoprevention