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AO 128
alpha-glucosidase inhibitor; structure given in first source
Also Known As:
AO-128; epi-Inositol, 2,3-dideoxy-2-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-4-C-(hydroxymethyl)-
Networked:
7
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclohexanes: 3
Cyclohexanols: 41
AO 128: 7
Alcohols: 595
Fatty Alcohols: 172
Hexanols: 17
Cyclohexanols: 41
AO 128: 7
Lipids: 114793
Fatty Alcohols: 172
Hexanols: 17
Cyclohexanols: 41
AO 128: 7
Related Diseases
1.
Insulin Resistance
03/01/1997 - "
The present study suggested that there were at least two, components of insulin resistance, a genetically determined and a poor-glycemic control-related, and that the latter insulin resistance was ameliorated by AO-128.
"
03/01/1997 - "
Slight but significant improvement of insulin resistance of Wistar fatty rats by treatment with a disaccharidase inhibitor, AO-128.
"
03/01/1997 - "
To know whether the insulin resistance is improved by delaying carbohydrate absorption from the small intestine, we studied the effect of a disaccharidase inhibitor, AO-128, on insulin resistance of Wistar fatty rats.
"
2.
Obesity
11/01/1995 - "
These findings indicate that AO-128 may be useful for treating human obesity and diabetes.
"
02/01/1992 - "
These findings indicate that AO-128 may be useful for treating human obesity and diabetes.
"
01/01/1992 - "
Thus, AO-128 is useful as an adjunct to the dietary management of obesity and diabetes.
"
3.
Diarrhea
10/01/1998 - "
Seven patients treated with AO-128 developed diarrhea, as compared with none in the placebo group (P < 0.05).
"
11/01/1995 - "
This decrease in food intake could hardly be explained only by diarrhea which occurred for the first 5 days of the administration of AO-128.
"
01/01/1992 - "
Undesirable side effects, such as diarrhea and soft feces, were observed only for the first 5-7 d and suppression of intestinal disaccharidase activities was observed even at the end of the experiment, suggesting that the suppressive or delaying effect of AO-128 on elevation of the postprandial blood glucose concentrations is involved in reduction in body weight gain and prevention and/or amelioration of the diabetic state.
"
4.
Body Weight (Weight, Body)
11/01/1995 - "
In addition, AO-128 decreased body weight gain, food efficiency, epididymal adipose tissue weight, carcass weight, and body fat deposition.
"
02/01/1992 - "
The high dose of AO-128 reduced food intake and body weight gain throughout the experimental period.
"
01/01/1992 - "
Undesirable side effects, such as diarrhea and soft feces, were observed only for the first 5-7 d and suppression of intestinal disaccharidase activities was observed even at the end of the experiment, suggesting that the suppressive or delaying effect of AO-128 on elevation of the postprandial blood glucose concentrations is involved in reduction in body weight gain and prevention and/or amelioration of the diabetic state.
"
5.
Hypertriglyceridemia
02/01/1992 - "
Hypertriglyceridemia tended to be suppressed by the AO-128 treatment.
"
11/01/1995 - "
AO-128 normalized hyperglycemia and markedly reduced hypertriglyceridemia and hyperinsulinemia in fatty rats.
"
Related Drugs and Biologics
1.
Disaccharidases
2.
Carbohydrates
3.
Glycoside Hydrolase Inhibitors
4.
Blood Glucose (Blood Sugar)
Related Therapies and Procedures
1.
Glycemic Control