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bryostatin 2
semisynthetic cpd from Ectoprocta (Bryozoa); activates protein kinase C
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Lactones: 1549
Polyketides: 231
Macrolides: 4391
Bryostatins: 121
bryostatin 2: 1
Polyether Polyketides: 22
Polyether Toxins: 28
Bryostatins: 121
bryostatin 2: 1
Ethers: 242
Cyclic Ethers: 12
Polyether Polyketides: 22
Polyether Toxins: 28
Bryostatins: 121
bryostatin 2: 1
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Polyketides: 231
Polyether Polyketides: 22
Polyether Toxins: 28
Bryostatins: 121
bryostatin 2: 1
Cyclic Ethers: 12
Polyether Polyketides: 22
Polyether Toxins: 28
Bryostatins: 121
bryostatin 2: 1
Biological Factors: 2472
Biological Toxins: 20
Marine Toxins: 124
Polyether Toxins: 28
Bryostatins: 121
bryostatin 2: 1
Related Diseases
1.
Lymphoid Leukemia
04/01/1992 - "
Reduction of the side-chain diene system to saturated ester 2a (P388 cell line ED50 8.5 x 10(-3) micrograms/ml) did not significantly affect the murine P388 cell line inhibition by bryostatin 2. Further hydrogenation to hexahydro derivative 2b gave a reduced P388 ED50 of 5.1 x 10(-2) micrograms/ml. Conversion to the octahydrobryostatin 2c caused a further reduction of P388 cell line activity to ED50 2.9 x 10(-1) micrograms/ml. Other structural modifications of bryostatin 2 in respect to esterification at the C-7 position significantly affected the P388 lymphocytic leukemia cell line response.
"
Related Drugs and Biologics
1.
Esters