|1.||Létienne, Robert: 1 article (01/2006)|
|2.||Le Grand, Bruno: 1 article (01/2006)|
|3.||Vié, Bruno: 1 article (01/2006)|
|4.||Decking, Ulrich K M: 1 article (09/2003)|
|5.||Hartmann, Matthias: 1 article (09/2003)|
01/01/1995 - "The results strongly suggest that R 56865 affords protection against the deleterious effects of moderate ischemia by mechanisms not associated with an indirect reduction of cardiac work. "
09/01/2003 - "Since slowly-inactivating Na(+)-channels may contribute to Na(+)-influx in ischemia, we investigated whether the ischemia-protective properties of R 56865, an inhibitor of slowly inactivating Na(+)-channels, are mediated by inhibition of the ischemic Na(+)-overload. "
08/06/1999 - "The electrophysiological effects of N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazo lamine (R56865), a drug which protects heart cells from ischemia-induced arrhythmias, was studied on intracellularly-recorded CA1 neurons of the rat hippocampal slice under normal or hypoxic conditions. "
08/01/1995 - "R56865 given before ischemia potently inhibits delayed sustained fibrillation occurring during reperfusion in the concentration range between 0.01 mumol/l and 0.1 mumol/l. "
08/01/1995 - "R56865 was given before ischemia and with the onset of reperfusion, applying different dosing schedules, including an initial loading dose. "
12/01/1993 - "R56865 improved the recovery of function and prevented contracture during reperfusion. "
10/06/1987 - "extrasystoles and contracture, as well as the development of spike-like action potentials could be prevented by pretreatment with R 56865 (3 X 10(-10)-10(-6) mol/l). "
09/01/2003 - "R 56865, however, showed marked cardioprotective properties: in the reperfusion period the agent markedly improved the restoration of left ventricular developed pressure (29.1+/-6.8 mm Hg vs. 2.4+/-2.0 mm Hg), ATP (2.8+/-0.3 mM vs. 1.7+/-0.6 mM) and phosphocreatine (10.9+/-2.2 mM vs. 6.8+/-1.1 mM), furthermore contracture development was reduced. "
12/01/1993 - "The effect on ischemic injury was evaluated by comparing myocardial contracture and contents of ATP catabolites and of lactate during 60 min of normothermic ischemia in untreated hearts (group I) and in hearts treated with 0.63 mg/kg of R56865 starting 20 min before ischemia (group II; n = 5 in each group). "
08/01/1993 - "Tetrodotoxin (TTX), prazosin, WB 4101 and R 56865 (0.1-10 microM) prevented tetanic contracture elicited by veratrine (100 micrograms/ml) at concentrations which were significantly lower than those which decreased active tension development. "
|3.||Coronary Artery Disease (Coronary Atherosclerosis)
|4.||Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1995 - "Attenuation by R 56865, a novel cytoprotective drug, of regional myocardial ischemia- and reperfusion-induced electrocardiographic disturbances in anesthetized rabbits."
09/01/1991 - "R 56865 is an experimental compound that has been shown to ameliorate the effects of cardiac glycoside toxicity and myocardial ischemia. "
12/01/1993 - "R56865, a Na(+)- and Ca(2+)-overload inhibitor, reduces myocardial ischemia-reperfusion injury in blood-perfused rabbit hearts."
01/01/1995 - "We investigated the antiischemic and antiarrhythmic effects of R 56865 in pentobarbital-anesthetized, open-chest rabbits subjected to 10 min regional myocardial ischemia and 20 min reperfusion, using two experimental protocols. "
12/01/1993 - "We conclude that R56865 could attenuate Ca(2+)-overload, thereby reducing myocardial ischemia-reperfusion injury after an extended period of ischemia."
08/06/1999 - "Despite its influence on repetitive firing properties, R56865 might be useful to limit the extent of cellular depolarizing responses to hypoxia."
08/06/1999 - "On hypoxic cells R56865 selectively reduced the amplitude of hypoxia-induced membrane depolarization and partly counteracted the depression of synaptic transmission evoked by Schaffers collateral stimulation. "
08/06/1999 - "Electrophysiological actions of N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazola mine (R56865) on CA1 neurons of the rat hippocampal slice during hypoxia."
09/01/1992 - "Myocytes were also exposed to hypoxia in the presence of R 56865, a compound that blocks noninactivating components of the Na+ current. "
09/01/1994 - "The purported Na+ overload blocker R 56865, significantly reduced maximal anoxic [Ca2+]i to 533 +/- 56 nM (P < 0.05), implicating a role of elevated intracellular Na+ in the anoxia-induced increase in [Ca2+]i. Veratridine (30 microM), with induces Na+ overload, increased [Ca2+]i to 787 +/- 39 nM. The compound R 56865 reduced veratridine-induced increases in [Ca2+]i to 152 +/- 38 nM. Upon reperfusion, after 45 min of anoxia, two distinct responses were observed. "
|2.||Adenosine Triphosphate (ATP)
|4.||Ouabain (G Strophanthin)
|8.||tranilast (N 5')
|1.||Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)