fusarochromanone

from Fusarium sp.; consists of an amino acid bearing chromone

Also Known As:

5-amino-6-(3-amino-4-hydroxybutanoyl)-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one; TDP-1 chromone; fusarochromenone; 4H-1-Benzopyran-4-one, 5-amino-6-(3-amino-4-hydroxy-1-oxobutyl)-2,3-dihydro-2,2-dimethyl-

Networked: 12 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        fusarochromanone: 12
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        fusarochromanone: 12

Experts

1.	Mahdavian, Elahe: 3 articles (12/2015 - 09/2014)
2.	Salvatore, Brian A: 3 articles (12/2015 - 09/2014)
3.	Williams-Hart, Tara: 2 articles (12/2015 - 09/2014)
4.	Furmanski, Brian D: 2 articles (09/2014 - 12/2009)
5.	Dréau, Didier: 2 articles (12/2009 - 09/2007)
6.	Wuthier, Roy E: 2 articles (12/2009 - 09/2007)
7.	El-Saadi, Madison Wynne: 1 article (12/2015)
8.	Adelmund, Steven: 1 article (09/2014)
9.	Barzegar, Mansoureh: 1 article (09/2014)
10.	Bhinge, Kaustubh N: 1 article (09/2014)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 09/01/2014 - "In the present study, we investigated the efficacy of the fungal metabolite, fusarochromanone (FC101), for its antitumor activities in glioblastomas, which have a median survival of less than two years and a poor clinical response to surgical resection, radiation therapy and chemotherapy. " 09/01/2014 - "Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone."
2.	Neoplasms (Cancer) 11/12/2022 - "Fusarochromanone is an experimental drug with unique and potent anti-cancer activity. " 12/01/2015 - "Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agent." 09/03/2014 - "Fusarochromanone (FC101) is a small molecule fungal metabolite with a host of interesting biological functions, including very potent anti-angiogenic and direct anti-cancer activity. " 09/03/2014 - "Biological activities of fusarochromanone: a potent anti-cancer agent." 12/01/2009 - "Differential uptake and selective permeability of fusarochromanone (FC101), a novel membrane permeable anticancer naturally fluorescent compound in tumor and normal cells."
3.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 04/01/1988 - "Tibial dyschondroplasia was induced in broiler chickens by oral administration of fusarochromanone, the toxic component of Fusarium equiseti. " 04/01/1993 - "Tibial dyschondroplasia of chickens induced by Fusarochromanone, a mycotoxin." 12/01/1989 - "The mycotoxin fusarochromanone, a metabolite of Fusarium fungi, is able to induce tibial dyschondroplasia (TD) in chickens under experimental conditions. " 12/01/1989 - "Natural occurrence of the mycotoxin fusarochromanone, a metabolite of Fusarium equiseti, in cereal feed associated with tibial dyschondroplasia." 07/01/1994 - "Many conditions have been found to induce tibial dyschondroplasia, including copper deficiency; fusarochromanone, thiram, and antabuse intoxication; excessive dietary levels of cysteine and homocysteine; metabolic acidosis; and bird rearing environment. "
4.	Carcinogenesis 12/01/2015 - "Fusarochromanone (FC101a) is a small molecule fungal metabolite exhibiting potent in-vitro growth inhibitory effects and is capable of inducing apoptosis, suppressing angiogenesis and tumorigenesis, and inhibiting endothelial cell growth in multiple cancer cell lines. "
5.	Kashin-Beck Disease 10/01/1987 - "The findings lend no support to the hypothesis that fusarochromanone, at least in unmodified form, is the etiologic agent in Kashin-Beck disease."

Related Drugs and Biologics

1.	Mycotoxins
2.	Caspase 3 (Caspase-3)
3.	Caspases
4.	Thiram
5.	Homocysteine
6.	Disulfiram (Antabuse)
7.	Cysteine (L-Cysteine)
8.	Copper

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration