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4,5-dimethyl-3-hydroxy-2(5H)-furanone (sotolone)

Also Known As:

sotolone; sotolon

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - 4,5-dimethyl-3-hydroxy-2(5H)-furanone: 8

Experts

1.	Abbas, Hisham A: 2 articles (07/2021 - 03/2021)
2.	Goda, Reham M: 2 articles (07/2021 - 03/2021)
3.	Alkhodairy, Salman F: 1 article (02/2022)
4.	Alotaibi, Abdullah D: 1 article (02/2022)
5.	Anwar, Sadaf: 1 article (02/2022)
6.	Arif, Jamal M: 1 article (02/2022)
7.	Kausar, Mohd Adnan: 1 article (02/2022)
8.	Khalifa, Amany Mohammed: 1 article (02/2022)
9.	Khan, Mohammad Kalim Ahmad: 1 article (02/2022)
10.	Khatoon, Fahmida: 1 article (02/2022)

Related Diseases

1.	Maple Syrup Urine Disease 08/01/2001 - "Fenugreek, maple syrup and the urine of maple syrup urine disease (MSUD) patients all share a characteristic odour originating from a common component, sotolone. " 04/01/1999 - "We have shown that sotolone is responsible for the characteristic odour of maple syrup urine disease and, since maple syrup also contains sotolone, the naming of this disease appears to be correct." 04/01/1999 - "Using enantioselective multidimensional gas chromatography-mass spectrometry (enantio-MDGC-MS), we could demonstrate that 4,5-dimethyl-3-hydroxy-2[5H]-furanone (sotolone), a well-known flavour impact compound present in fenugreek and lovage, was present in urine from seven patients with maple syrup urine disease. " 04/01/1999 - "4,5-dimethyl-3-hydroxy-2[5H]-furanone (sotolone)--the odour of maple syrup urine disease."
2.	Infections 03/01/2021 - "In conclusion, sotolon is an anti-virulence agent that could be used for the treatment of S.marcescens hospital-acquired infections." 12/01/2001 - "3-Hydroxy-4,5-dimethyl-2(5H)-furanone (sotolone) and 3-amino-4,5-dimethyl-2(5H)-furanone, the postulated precursor of sotolone, were detected in hairy root cultures of Trigonella foenum-graecum (fenugreek) by GC-MS. The hairy root cultures in both conical flasks and airlift with mesh bioreactors were achieved from hypocotyl of seedling by infection with Agrobacterium rhizogenes. "
3.	Premature Aging 06/23/2010 - "Sotolon (3-hydroxy-4,5-dimethyl-2(5H)-furanone) is a chiral furanone, an aroma compound known to be responsible for premature-aging flavor in dry white wines. "
4.	Wounds and Injuries (Trauma) 12/01/2023 - "Treatment with a sotolon loaded aerogel yielded a 5.16 log reduction in viable biofilm bound cells in a novel model of chronic wound biofilm, equivalent to the current wound therapy Aquacel AG. "
5.	Type 2 Diabetes Mellitus (MODY) 02/04/2022 - "The research aims to identify the inhibitory potential of natural dietary phytochemicals against non-insulinotropic target protein alpha-glucosidase and its possible implications to diabetes mellitus type 2. A data set of sixteen plant-derived dietary molecules viz., 4,5-dimethyl-3-hydroxy-2(5H)-furanone, apigenin, bromelain, caffeic acid, cholecalciferol, dihydrokaempferol 7-o-glucopyranoside, galactomannan, genkwanin, isoimperatorin, luteolin, luteolin 7-o-glucoside, neohesperidin, oleanoic acid, pelargonidin-3-rutinoside, quercetin, and quinic acid were taken to accomplish molecular docking succeeded by their comparison with known inhibitors including acarbose, miglitol, voglibose, emiglitate, and 1-deoxynojirimycin. "

Related Drugs and Biologics

1.	Phytochemicals
2.	Luteolin
3.	Apigenin
4.	Acarbose
5.	1-Deoxynojirimycin (1 Deoxynojirimycin)
6.	Quinic Acid (Quinate)
7.	Quercetin
8.	Proteins (Proteins, Gene)
9.	Cholecalciferol (Vitamin D3)
10.	Carboxymethylcellulose Sodium (Polycell)

Related Therapies and Procedures

1.	Bioreactors (Bioreactor)
2.	Therapeutics