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leucine thiorphan

enkephalinase inhibitor

Also Known As:

Leu-thiorphan

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Amino Acids: 221
    - Thiorphan: 64
      - leucine thiorphan: 2
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - N-substituted Glycines
      - Thiorphan: 64
        leucine thiorphan: 2
  - Sulfur Amino Acids: 221
    - Thiorphan: 64
      - leucine thiorphan: 2

Related Diseases

1.

09/01/1989 - "Enkephalinase (120 micrograms) inhibited cough induced by subsequent exposure to substance P compared with the response to substance P alone, but after further exposure to the enkephalinase inhibitor leucine-thiorphan (10(-5) M), substance P increased cough significantly. "
12/01/1988 - "Leucine-thiorphan (10(-5) M) and phosphoramidon (10(-5) M) potentiated substance P-induced cough; NEP inhibitors also potentiated capsaicin-induced cough significantly. "
12/01/1988 - "To study the roles of substance P and endogenous neutral endopeptidase in mediating cough, we measured cough responses in awake guinea pigs in response to exogenous substance P and capsaicin aerosols in the presence and absence of the neutral endopeptidase inhibitors leucine-thiorphan and phosphoramidon. "

Related Drugs and Biologics

1.	Neprilysin (Neutral Endopeptidase)
2.	Substance P
3.	Capsaicin (Zostrix)
4.	Aerosols
5.	phosphoramidon