|1.||Karp, F: 1 article (06/2001)|
|2.||Schalk, M: 1 article (06/2001)|
|3.||Croteau, R: 1 article (06/2001)|
|4.||Maffei, M: 1 article (06/2001)|
|5.||Bertea, C M: 1 article (06/2001)|
|1.||Dehydration (Water Stress)
09/01/1987 - "Menthofuran was identified as a proximate toxic metabolite of (R)-(+)-pulegone, and investigations with (R)-(+)-pulegone-d6 and 18O2 strongly indicate that menthofuran is formed by a sequence of reactions that involve: 1) oxidation of an allylic methyl group, 2) intramolecular cyclization to form a hemiketal, and 3) dehydration to form the furan."
06/15/2001 - "Microsomal preparations, from the oil gland secretory cells of a high (+)-menthofuran-producing chemotype of Mentha pulegium, transform (+)-pulegone to (+)-menthofuran in the presence of NADPH and molecular oxygen, implying that menthofuran is synthesized by a mechanism analogous to that of mammalian liver cytochrome P450s involving the hydroxylation of the syn-methyl group of (+)-pulegone, spontaneous intramolecular cyclization to the hemiketal, and dehydration to the furan. "
|2.||Body Weight (Weight, Body)
03/01/1992 - "Menthofuran (II) was administered orally (200 mg/kg of the body weight/day) to rats for 3 days. "
05/31/1991 - "Menthofuran (II, 4,5,6,7-tetrahydro-3,6-dimethyl benzofuran), the proximate toxin of R-(+)-pulegone (I), was administered orally to rats (200 mg/kg of body weight/day) for three days and the urinary metabolites were investigated. "