|1.||Sen, Ellora: 3 articles (01/2015 - 08/2009)|
|2.||Yeung, Sai-Ching Jim: 3 articles (10/2008 - 03/2002)|
|3.||Zhu, Xiao-Feng: 3 articles (08/2005 - 06/2003)|
|4.||Liu, Zong-Chao: 3 articles (08/2005 - 06/2003)|
|5.||Zhou, Jun-Min: 3 articles (08/2005 - 06/2003)|
|6.||Pan, Qi-Chao: 3 articles (08/2005 - 06/2003)|
|7.||Daino, Hanako: 2 articles (03/2015 - 04/2008)|
|8.||Carey, Gregory B: 2 articles (03/2015 - 04/2008)|
|9.||Ghosh, Sadashib: 2 articles (01/2015 - 08/2009)|
|10.||She, Miao-Rong: 2 articles (01/2014 - 08/2008)|
|1.||Prostatic Neoplasms (Prostate Cancer)
01/01/2014 - "These results suggest that manumycin may be beneficial for the treatment of prostate cancer."
01/01/2014 - "In the current study, we further evaluated the effect of manumycin in two prostate cancer cell lines (LNCaP and 22Rv1), and here we elucidate some of the underlying mechanisms. "
01/01/2014 - "Manumycin induces apoptosis in prostate cancer cells."
01/01/2014 - "Manumycin exhibits an antitumor effect in a variety of cancer cell lines, including prostate cancer cell lines (DU145 and PC-3). "
01/01/2014 - "Our data suggest that manumycin induces apoptosis in prostate cancer cells through regulation of the Bcl-2 family involving caspase-9 activation. "
|2.||Colorectal Neoplasms (Colorectal Cancer)
08/01/2008 - "Our previous study showed DNA damage response induced by manumycin in cancer cells. "
04/01/2012 - "In addition, manumycin also decreased IL-1β induced pro-inflammatory responses in tumor cells."
02/03/2006 - "Most importantly, administration of manumycin A to mice xenografted with murine B16F10 tumors caused potent IKK-suppressive effects. "
09/05/2002 - "Manumycin A is a natural antibiotic produced by Streptomyces parvulus that has antineoplastic activity against a variety of human cancers in nude mouse models. "
08/01/2005 - "The mean tumor volume ratio of nude mice xenograft (V/V(0)) was significantly lower in low dose manumycin group and high dose manumycin group than in negative control group (0.68+/-0.09 and 0.59+/-0.04 vs. 1.38+/-0.21, P < 0.01). "
02/01/2000 - "The aim of the present study was to assess the cytotoxicity of manumycin, a specific inhibitor of farnesyl:protein transferase, as well as its effects on protein isoprenylation and kinase-dependent signal transduction in COLO320-DM human colon adenocarcinoma which harbours a wild-type K-ras gene. "
01/01/2011 - "Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A."
01/01/2011 - "In this study, the combined effect of hypericin (the photodynamically-active pigment from Hypericum perforatum) and selective farnesyltransferase inhibitor manumycin (manumycin A; the selective farnesyltransferase inhibitor from Streptomyces parvulus) on HT-29 adenocarcinoma cells was examined. "
|5.||Hepatocellular Carcinoma (Hepatoma)
04/01/2002 - "This study was designed to investigate the antitumor effect of Manumycin in human hepatoma cell line HepG2 and try to clarify its influence on Ras pathway. "
02/03/2006 - "To identify the molecular mechanisms of manumycin A action, cultured human HepG2 hepatoma cells were transiently transfected with various IKKalpha and IKKbeta constructs, and a striking difference in manumycin A sensitivity was observed. "
08/01/2005 - "Our previous experiments showed that manumycin could inhibit proliferation pathway and survival pathway in human hepatocellular carcinoma HepG2 cells in vitro. "
12/01/2003 - "Manumycin induces apoptosis in human hepatocellular carcinoma HepG2 cells."
06/01/2003 - "Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells."
|5.||anaplastic Thyroid cancer
|10.||lonafarnib (SCH 66336)
|3.||Heterologous Transplantation (Xenotransplantation)