parathyroid hormone-related protein (1-34)

exhibits parathyroid-like vasorelaxation in renal arteries; found in neoplasms and normal tissue

Also Known As:

PTH-like protein (1-34); PTHrP (1-34); PTHrP(1-34); hHCF-(1-34)-NH2; hHF (1-34); hPLP (1-34); hPTH-related protein (1-34); human hypercalcemia factor; hypercalcemic hormone of malignancy (1-34); parathyroid hormone-like protein (1-34); tumor hypercalcemic factor (1-34)

Networked: 55 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sato, Koh: 3 articles (11/2005 - 09/2003)
2.	Ogata, Etsuro: 2 articles (11/2005 - 09/2004)
3.	Onuma, Etsuro: 2 articles (11/2005 - 09/2004)
4.	Saito, Hidemi: 2 articles (11/2005 - 09/2004)
5.	Tsunenari, Toshiaki: 2 articles (11/2005 - 09/2004)
6.	Yamada-Okabe, Hisafumi: 2 articles (11/2005 - 09/2004)
7.	Datta, Nabanita S: 1 article (04/2022)
8.	Lanske, Beate: 1 article (04/2022)
9.	Przyklenk, Karin: 1 article (04/2022)
10.	Undyala, Vishnu V R: 1 article (04/2022)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/1994 - "Four groups of 7-8-month-old rats were treated sc daily for 13 d with PTHrP (1-34) or (107-111) at the dose of 1 or 3 nmol/100 g body weight. " 09/01/2013 - "We found that subcutaneous injection of PTHrP(1-34) (40 or 80 μg/kg body weight every day) in OVX rats increased lumbar and femoral BMD, improved bone biomechanical properties, enhanced bone strength, and promoted bone formation. "
2.	Neoplasms (Cancer) 03/05/1993 - "FTIR spectroscopy study of PTHrP(1-34) involved in humoral hypercalcaemia of malignancy." 09/01/2005 - "Abundant positive immunoreactivity for anti-PTHrP (1-34) antibody was recognized diffusely in the whole cytoplasm of many tumor cells. " 09/01/2005 - "The intensity of PTHrP was proportionally related to the degree of differentiation or extent of keratinization (P < 0.05) and the histologic malignancy grade of the tumor (P < 0.05), when using antibody against PTHrP (1-34), but not when using antibody against PTHrP (38-64). " 09/15/2001 - "Although neutralizing antibodies stimulated BEN cell lung tumor growth, exogenous PTHrP 1-34 treatment (0.01-1 nM) inhibited the growth of cultured BEN cells by approximately 40%. " 11/01/1988 - "The amino-terminal fragment of a tumor parathyroid hormone-related peptide (PTHrP(1-34] produced by a human squamous cell carcinoma of the lung was recently synthesized. "
3.	Osteoporosis 09/01/2013 - "We used an ovariectomized (OVX) rat model of osteoporosis to study the effects of PTHrP(1-34) on bone metabolism by measuring bone mineral density (BMD), bone histomorphometrics, and biomechanical parameters. " 01/01/2014 - "Recombinant human parathyroid hormone related protein 1-34 and 1-84 and their roles in osteoporosis treatment." 09/01/2013 - "Effects of different dosages of parathyroid hormone-related protein 1-34 on the bone metabolism of the ovariectomized rat model of osteoporosis." 05/01/2016 - "Abaloparatide is an investigational analog of human PTHrP (1-34) being developed for the treatment of osteoporosis. " 09/01/2013 - "Based on our results, intermittent low-dose PTHrP(1-34) injection promoted bone formation in OVX rats, suggesting a high potential for therapeutic use in osteoporosis patients."
4.	Bone Resorption 01/01/2019 - "Thus, we aimed to investigate the effect of PTHrP (1-34) on bone resorption and osteogenesis of DFCs in vitro and in vivo. " 04/01/1995 - "PTHrP (1-34), like PTH (1-34) fragments, might be responsible for both bone resorption and formation. " 11/01/2017 - "Intermittent administration of PTHrP (1-34) exhibited an inhibitory effect on alveolar bone resorption and the gingival inflammation in periodontal tissues of diabetic rats." 12/11/1987 - "PTHrP(1-34) had only 6% of the potency of bovine PTH(1-34) in promoting bone resorption in vitro. " 01/01/1993 - "We conclude that PTHrP(1-34) causes similar effects on bone, in organ cultures, to those caused by bPTH(1-34), namely an increase in both bone resorption and formation and a decrease in the vitamin D-stimulated BGP synthesis."
5.	Carcinoma (Carcinomatosis) 03/01/1990 - "The serum level of PTHrP was examined using human PTHrP (1-34) RIA in lung carcinomas. " 09/15/2001 - "Although PTHrP expression has been reported to be associated with more aggressive malignancies, the data from the current study suggest that PTHrP 1-34 was a paracrine growth inhibitor in BEN human lung carcinoma cells. " 01/01/1997 - "It has been previously reported that 8701-BC cells, derived from a primary carcinoma of the breast, constitutively express parathyroid hormone (PTH)-related peptide (PTHrP) and PTH/PTHrP receptor (PTH/PTHrP-R) genes, that N-terminal, mid-regional and C-terminal immunoreactive PTHrP can be found in cell conditioned medium and, furthermore, that exogenously added PTHrP (1-34), (67-86) and, to a minor extent, (107-139) are anti-mitogenic but promote Matrigel invasion by this cell line. "

Related Drugs and Biologics

1.	Parathyroid Hormone-Related Protein
2.	abaloparatide
3.	Immune Sera (Antisera)
4.	Growth Inhibitors
5.	Coloring Agents (Dyes)
6.	Parathyroid Hormone (Parathormone)
7.	Peptides (Polypeptides)
8.	Adenylyl Cyclases (Adenylyl Cyclase)
9.	Acids
10.	bovine parathyroid hormone (1-34)

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Therapeutics
3.	Ovariectomy (Oophorectomy)