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lantibiotic Pep5

from staphylococcus epidermidis 5; antibiotic with membrane-disruptive action; induces autolysis in staphylococci

Also Known As:

Pep 5; Pep 5 staphylococcin

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Bacteriocins: 556
        lantibiotic Pep5: 7
  - Bacterial Proteins: 394
    - Bacteriocins: 556
      - lantibiotic Pep5: 7

Experts

1.	Chen, Jinhong: 1 article (03/2017)
2.	Du, Guiqiang: 1 article (03/2017)
3.	Li, Bilan: 1 article (03/2017)
4.	Lu, Wen: 1 article (03/2017)
5.	Wan, Xiaoping: 1 article (03/2017)
6.	Zhang, Yongli: 1 article (03/2017)

Related Diseases

1.	Squamous Cell Carcinoma of Head and Neck 08/01/1997 - "In the present study, we investigated the clinical and histopathological effects of CP therapy consisting of cisplatin (CDDP 50 mg/m2) or carboplatin (CBDCA 300 mg/m2) and peplomycin (PEP 5 mg/day) for 25 patients with oral squamous cell carcinoma. "
2.	Autolysis 04/01/1985 - "Pep 5 and nisin are cationic bactericidal peptides which were shown to induce autolysis in Staphylococcus cohnii 22. " 12/01/1987 - "Pep 5 and nisin are cationic peptide antibiotics which in addition to their membrane-disruptive action induce autolysis in staphylococci. " 04/01/1985 - "Induction of autolysis of staphylococci by the basic peptide antibiotics Pep 5 and nisin and their influence on the activity of autolytic enzymes."
3.	Ectopic Pregnancy 03/01/2017 - "Repeat ectopic pregnancy (REP) tended to occur more frequently in PEP patients (PEP: 5 cases, 10.20%; non-PEP: 4 cases, 2.80%; P = 0.034). "
4.	Dehydration (Water Stress) 11/26/1990 - "The results strongly suggest that maturation of the lantibiotic Pep5 is initiated by selective dehydration of hydroxyamino acids in the propeptide region of the primary translation product and that thioether ring formation is not closely linked to dehydration."
5.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/1988 - "Seventeen patients with recurrent uterine cervical cancer were treated with combination chemotherapy consisting of consecutive intravenous drip infusion of PEP 5 mg for 6 days and intravenous infusion of MMC 10 mg on the 6th day. "

Related Drugs and Biologics

1.	Peplomycin
2.	Carboplatin (JM8)
3.	Cisplatin (Platino)
4.	Peptides (Polypeptides)
5.	Nisin
6.	Anti-Bacterial Agents (Antibiotics)
7.	Sulfides (Thioethers)
8.	Enzymes
9.	Acids

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Infusions
3.	Combination Drug Therapy (Combination Chemotherapy)