|1.||Schrauwen, Patrick: 2 articles (01/2014 - 07/2012)|
|2.||Hesselink, Matthijs K C: 2 articles (01/2014 - 07/2012)|
|3.||Nabben, Miranda: 2 articles (01/2014 - 07/2012)|
|4.||Schaart, Gert: 2 articles (01/2014 - 07/2012)|
|5.||Lenaers, Ellen: 2 articles (01/2014 - 07/2012)|
|6.||van Beurden, Denis: 2 articles (07/2012 - 04/2011)|
|7.||Rupp, Heinz: 2 articles (03/2002 - 03/2002)|
|8.||Vetter, R: 2 articles (12/2000 - 10/2000)|
|9.||Broom, Oliver Jay: 1 article (08/2015)|
|10.||Stäubert, Claudia: 1 article (08/2015)|
03/01/2002 - "Also, the first clinical trial with etomoxir in patients with heart failure showed that etomoxir improved the clinical status and several parameters of heart function. "
01/01/2014 - "Interestingly, etomoxir, a fat oxidation inhibitor and strong inducer of UCP3, is proposed for treating both diabetes and heart failure. "
09/01/2009 - "We tested whether application of two agents (etomoxir and NVP-LAB121) capable of inducing a substrate-switch reverts the onset of heart failure in rats with chronic pressure-overload. "
03/01/2002 - "[Functional genomics of pressure-loaded cardiomyocytes: etomoxir in heart failure?]."
11/11/2000 - "Etomoxir: a new approach to treatment of chronic heart failure."
|2.||Cardiomegaly (Heart Hypertrophy)
06/30/1999 - "Rats were treated with etomoxir, an inhibitor of palmitoyltransferase-1, to examine the role of a shift in myocardial metabolism in cardiac hypertrophy. "
09/01/1996 - "Modification of sarcoplasmic reticulum gene expression in pressure overload cardiac hypertrophy by etomoxir."
10/06/2000 - "Thus, induction of mild cardiac hypertrophy by etomoxir in rats with small infarctions may be beneficial for myocardial performance."
10/06/2000 - "Etomoxir induced cardiac hypertrophy in animals with small infarctions, and enhanced compensatory heart growth at large infarct size. "
02/01/2003 - "Overall, the findings here presented show that etomoxir treatment may induce cardiac hypertrophy via increased cellular oxidative stress and NF-kappaB activation."
|3.||Type 2 Diabetes Mellitus (MODY)
11/01/1991 - "To determine the therapeutic effect of the carinitine palmitoyltransferase I (CPT-I) inhibitor, etomoxir, eight hospitalized obese non-insulin-dependent diabetes mellitus (NIDDM) patients were studied (body mass index [BMI], 28.7 +/- 1.3 kg/m2; age, 54 +/- 8 years [means +/- SE]) at baseline (placebo = t1), and after oral etomoxir (50 mg/d = t2, 100 mg = 3, 150 mg = t4, 200 mg = t5, placebo = t6). "
09/01/1997 - "Effects of the carnitine-acyltransferase inhibitor etomoxir on insulin sensitivity, energy expenditure and substrate oxidation in NIDDM."
03/01/2002 - "Inhibitors of carnitine palmitoyl-transferase I (CPT I), the key enzyme for the transport of long-chain acyl-coenzyme A (acyl-CoA) compounds into mitochondria, have been developed as agents for treating diabetes mellitus Type 2. Findings that the CPT I inhibitor, etomoxir, has effects on overloaded heart muscle, which are associated with an improved function, were unexpected and can be attributed to selective changes in the dysregulated gene expression of hypertrophied cardiomyocytes. "
11/01/1991 - "Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus."
|4.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/01/2014 - "Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. "
01/01/2014 - "In this work we analyzed the apoptotic and chemo-sensitizing action of the fatty acid oxidation inhibitor etomoxir in human acute myeloid leukemia cells. "
01/01/2010 - "Importantly, etomoxir decreased the number of quiescent leukemia progenitor cells in approximately 50% of primary human acute myeloid leukemia samples and, when combined with either ABT-737 or cytosine arabinoside, provided substantial therapeutic benefit in a murine model of leukemia. "
|5.||Left Ventricular Dysfunction
|3.||Acyl Coenzyme A (Acyl CoA)
|4.||Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)
|6.||Messenger RNA (mRNA)
|8.||Proteins (Proteins, Gene)
|1.||Heterologous Transplantation (Xenotransplantation)