|1.||Sun, Lijuan: 1 article (05/2013)|
|2.||Fang, Fengkai: 1 article (05/2013)|
|3.||Zhang, Wen: 1 article (05/2013)|
|4.||Wang, Yi: 1 article (05/2013)|
|5.||Xiao, Shun: 1 article (05/2013)|
|6.||Zhang, Yufeng: 1 article (05/2013)|
|7.||Cheng, Yiyu: 1 article (05/2013)|
|8.||Ge, Zhiwei: 1 article (05/2013)|
|9.||Benaim, Gustavo: 1 article (01/2012)|
|10.||Sojo, Felipe: 1 article (01/2012)|
01/01/2012 - "The reproduction of the effects of agelasine B on cell viability and on the [Ca(2+)]( I ) obtained on SKBr3 and PC-3 cancer cells strongly suggests the generality of the mechanism of action of this toxin."
01/01/2012 - "In search for new drugs derived from natural products for the possible treatment of cancer, we studied the action of agelasine B, a compound purified from a marine sponge Agelas clathrodes. "
05/13/2013 - "In particular, two diterpenoid derivatives, agelasine B and (-)-agelasine D, were identified for the first time as anti-tumor compounds from the sponge Agelas mauritiana, showing a considerable activity toward MCF-7 cells (IC50 values of 7.84±0.65 and 10.48±0.84 μM, respectively). "
|2.||Prostatic Neoplasms (Prostate Cancer)
|3.||Breast Neoplasms (Breast Cancer)
01/01/2012 - "Upon agelasine B treatment, cell viability of both human breast cancer cell lines was one order of magnitude lower as compared with fibroblasts (IC(50) for MCF-7 = 2.99 μM; SKBr3: IC(50) = 3.22 μM vs. fibroblasts: IC(50) = 32.91 μM), while the IC(50) for PC-3 IC(50) = 6.86 μM. "
01/01/2012 - "The marine sponge toxin agelasine B increases the intracellular Ca(2+) concentration and induces apoptosis in human breast cancer cells (MCF-7)."
01/01/2012 - "Agelasine B was purified from a marine sponge Agelas clathrodes and assayed for cytotoxicity by MTT on two human breast cancer cells (MCF-7 and SKBr3), on a prostate cancer cells (PC-3) and on human fibroblasts. "