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Y 19995

synthetic compound affecting the host defence in immunocompromised mice
Also Known As:
2,4'-bis(1-methyl-2-dimethylaminoethoxy)-3-benzoylpyridine dimaleate; Y-19995
Networked: 2 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1. Leukopenia
08/01/1987 - "Effects of a novel synthetic compound, Y-19995, on the host defence in immunocompromised mice were investigated in terms of the restoration of leukocytopenia and the protection against several microbial infections. "
08/01/1987 - "The augmented protection against microbial infections in immunocompromised hosts by Y-19995 may be attributed mainly to the prevention of leukocytopenia or the enhanced restoration from leukocytopenia."
01/01/1991 - "The number of peripheral polymorphonuclear leukocytes in cyclophosphamide-treated mice rapidly decreased and returned to normal levels only 9 days after the treatment, while such leukocytopenia was prevented to some extent and the leukocyte count was restored completely up to 7 days by postcyclophosphamide treatment with Y-19995. "
01/01/1991 - "The relationship between depression of early protection against influenza virus infection and the decrease in the number of peripheral polymorphonuclear leukocytes in cyclophosphamide-treated mice was investigated by means of a novel synthetic compound, Y-19995 [2,4'-bis(1-methyl-2-dimethyl-aminoethoxyl)-3-benzoylpyridine dimaleate], which had been shown to exert a potent restorative effect on leukocytopenia in immunocompromised hosts. "
08/01/1987 - "Oral or intravenous administration of Y-19995 into mice after X-irradiation, treatment with cyclophosphamide or mitomycin C prevented the leukocytopenia to some extent and promoted the restoration in cell numbers of both the peripheral blood leukocytes and bone marrow. "
2. Infection

Related Drugs and Biologics

1. Cyclophosphamide (Cytoxan)
2. Mitomycin (Mitomycin-C)