E 5110

structure given in first source

Also Known As:

E-5110; N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-one; 2-Pyrrolidinone, 3-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-1-methoxy-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - E 5110: 3

Related Diseases

1.	Edema (Dropsy) 08/01/1987 - "The acute antiinflammatory activity of E-5110 on carrageenin paw edema was similar to IND, and half of PIR. " 08/01/1987 - "The acute antiinflammatory activity of E-5110 on the carrageenin paw edema was similar to that of indomethacin, and half that of piroxicam. "
2.	Arthus Reaction 08/01/1987 - "E-5110 inhibited the pleural exudate volume and leucocyte infiltration in a reversed passive Arthus reaction more potent than IND. " 08/01/1987 - "E-5110 decreased the pleural exudate volume and inhibited leucocyte infiltration in a reversed passive Arthus reaction more potently than indomethacin, suggesting that mediators other than prostaglandin E2 may play an important role in this inflammatory process. "
3.	Rheumatoid Arthritis 06/01/1989 - "It is expected that E-5110 will be superior to classical non-steroidal antiinflammatory drugs in medical treatment of rheumatoid arthritis." 08/01/1987 - "The chronic inflammatory responses in established adjuvant- and type II collagen-induced arthritis, which are widely used models of rheumatoid arthritis, were suppressed as effectively by E-5110 as by indomethacin and piroxicam. "
4.	Arthritis (Polyarthritis) 08/01/1987 - "The chronic inflammatory responses in the established adjuvant- and type II collagen-induced arthritis were suppressed by E-5110 similar to IND and PIR. " 08/01/1987 - "The chronic inflammatory responses in established adjuvant- and type II collagen-induced arthritis, which are widely used models of rheumatoid arthritis, were suppressed as effectively by E-5110 as by indomethacin and piroxicam. "
5.	Pain (Aches) 08/01/1987 - "The analgesic potency of E-5110 against inflammatory pain was similar to that of indomethacin or piroxicam, but the antipyretic activity of E-5110 was more potent than that of the reference drugs. "

Related Drugs and Biologics

1.	Collagen Type II (Type II Collagen)
2.	Carrageenan
3.	Antipyretics
4.	Dinoprostone (PGE2)
5.	Piroxicam (Feldene)
6.	Indomethacin (Indometacin)
7.	Analgesics (Analgesic Drugs)