niguldipine (dexniguldipine)

structure given in first source; clinical modulator of multidrug resistance

Also Known As:

dexniguldipine; 3-((4,4-diphenyl-1-piperidinyl)propyl)-5-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate hydrochloride; 3-methyl-5-(3-(4,4-diphenyl-1-piperidinyl)propyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate; B 844-39; B 859-35; B8509-035; B859-35; DNIG; niguldipine fumarate; niguldipine hydrobromide; niguldipine hydrochloride; niguldipine maleate

Networked: 35 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - niguldipine: 35

Experts

1.	Ju, Yan: 1 article (10/2018)
2.	Lan, Zhigang: 1 article (10/2018)
3.	Richard, Seidu A: 1 article (10/2018)
4.	Tan, Junya: 1 article (10/2018)
5.	Wei, Fu: 1 article (10/2018)
6.	Kew, Yvonne: 1 article (07/2011)
7.	Powell, Suzanne: 1 article (07/2011)
8.	Rangel-Castilla, Leonardo: 1 article (07/2011)
9.	Zhang, Yi Jonathan: 1 article (07/2011)
10.	Coburn, Robert A: 1 article (08/2005)

Related Diseases

1.	Seizures (Absence Seizure) 06/01/2002 - "The present results may argue against the use of niguldipine as an adjuvant antiepileptic or for cardiovascular reasons in patients with complex partial seizures." 06/01/2002 - "Niguldipine (at 7.5 but not at 5 mg/kg) displayed a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled convulsions in rats, a model of complex partial seizures. " 06/01/2002 - "Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats." 03/26/1997 - "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures. " 01/01/2004 - "In this review, we present anticonvulsant effects of cinnarizine, flunarizine, nifedipine, nimodipine, nicardipine, amlodipine, isradipine, niguldipine, diltiazem, verapamil and dantrolene in animal models of seizures. "
2.	Acute Erythroblastic Leukemia (Erythroleukemia) 01/01/1996 - "Given the importance of protein kinase C (PKC) activity in proliferation and differentiation, we examined the effect of DNIG on several parameters of Friend erythroleukemia cell (FELC) activity. " 01/01/1996 - "The newly synthesized dihydropyridine derivative B859-35 was previously shown in vitro to be highly effective in reversing multidrug resistance (MDR) of P-glycoprotein positive tumor cell lines, such as the adriamycin (ADR) resistant erythroleukemia F4-6RADR cells. " 01/01/1996 - "Dexniguldipine hydrochloride, a protein-kinase-C-specific inhibitor, affects the cell cycle, differentiation, P-glycoprotein levels, and nuclear protein phosphorylation in Friend erythroleukemia cells."
3.	Neoplasms (Cancer) 01/01/1996 - "In the current study B859-35 was investigated for its efficiency in reversing MDR in an in vivo tumor model for preclinical testing of MDR-modulators. " 08/16/1991 - "An application of this method to the study of pharmacokinetics of B859-35 in serum samples of cancer patients is given." 01/01/1997 - "Eleven tumor-bearing dogs were given a known non-nephrotoxic anticancer drug, dexniguldipine, as control. " 01/01/1997 - "Overall, tumor-tissue concentrations of M-1 comprised one-third of the dexniguldipine concentrations measured." 01/01/1997 - "High degrees of correlation (> 0.8) were established between the concentrations of dexniguldipine measured in plasma and tumor as well as renal tissue. "
4.	Lung Neoplasms (Lung Cancer) 01/01/1994 - "In this study, we have tested the hypothesis that dexniguldipine may inhibit the proliferation of lung cancer cells in response to autocrine or exogenous activation of PKC. " 12/01/1991 - "In this study, we have tested the antiproliferative effects of B859-35 and of the Ca(2+)-channel blocker Verapamil in vitro on three human lung cancer cell lines. " 06/01/1994 - "Experiments conducted with six human lung cancer cell lines showed that dexniguldipine is a potent inhibitor of EGF-stimulated cell proliferation. " 01/01/1994 - "Using a panel of human lung cancer cell lines, we show that dexniguldipine is a potent inhibitor of mitogenic signal transduction pathways dependent on PKC activation in several small-cell and non-small-cell lung cancer cell lines while it failed to inhibit cyclic-AMP-dependent cell proliferation." 06/01/1994 - "Effect of the dihydropyridine dexniguldipine on the epidermal growth factor-stimulated proliferation of human lung cancer cell lines."
5.	Carcinoma (Carcinomatosis) 01/01/1996 - "The chemosensitizing potency of dexniguldipine hydrochloride (B8509-035) on epidoxorubicin was assessed in a multidrug-resistant (MDR) tumour model, the intrinsic MDR rat colon carcinoma CC531. " 01/01/1996 - "Modulation of multidrug resistance with dexniguldipine hydrochloride (B8509-035) in the CC531 rat colon carcinoma model." 11/01/1995 - "These results suggest that the suppression of the growth of HT-29 colon carcinoma cells by DNIG involves the inhibition of the expression of PKC Delta and zeta." 05/01/1996 - "Thus, dexniguldipine-HCl efficiently modulated taxane resistances of the ovarian carcinoma MDR cell line 2780AD in the submicromolar concentration range, whereas cyclosporin A and the other chemosensitizers were rather ineffective. " 11/01/1995 - "Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta."

Related Drugs and Biologics

1.	1,4-dihydropyridine (dihydropyridine)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Anticonvulsants (Antiepileptic Drugs)
4.	Isradipine (Dynacirc)
5.	Dantrolene (Dantrium)
6.	Sodium
7.	Hydantoins
8.	Doxorubicin (Adriamycin)
9.	niguldipine (dexniguldipine)
10.	Verapamil (Calan)

Related Therapies and Procedures

1.	Therapeutics
2.	Surgical Amputation (Amputations)