|1.||Kew, Yvonne: 1 article (07/2011)|
|2.||Powell, Suzanne: 1 article (07/2011)|
|3.||Zhang, Yi Jonathan: 1 article (07/2011)|
|4.||Rangel-Castilla, Leonardo: 1 article (07/2011)|
|5.||Coburn, Robert A: 1 article (08/2005)|
|6.||Yang, Xinning: 1 article (08/2005)|
|7.||Zhou, Xiao-Fei: 1 article (08/2005)|
|8.||Wang, Qi: 1 article (08/2005)|
|9.||Morris, Marilyn E: 1 article (08/2005)|
|10.||Sobaniec, Wojciech: 1 article (01/2004)|
06/01/2002 - "The present results may argue against the use of niguldipine as an adjuvant antiepileptic or for cardiovascular reasons in patients with complex partial seizures."
06/01/2002 - "Niguldipine (at 7.5 but not at 5 mg/kg) displayed a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled convulsions in rats, a model of complex partial seizures. "
06/01/2002 - "Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats."
03/26/1997 - "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures. "
01/01/2004 - "In this review, we present anticonvulsant effects of cinnarizine, flunarizine, nifedipine, nimodipine, nicardipine, amlodipine, isradipine, niguldipine, diltiazem, verapamil and dantrolene in animal models of seizures. "
08/16/1991 - "An application of this method to the study of pharmacokinetics of B859-35 in serum samples of cancer patients is given."
01/01/1997 - "Eleven tumor-bearing dogs were given a known non-nephrotoxic anticancer drug, dexniguldipine, as control. "
01/01/1997 - "Overall, tumor-tissue concentrations of M-1 comprised one-third of the dexniguldipine concentrations measured."
01/01/1997 - "High degrees of correlation (> 0.8) were established between the concentrations of dexniguldipine measured in plasma and tumor as well as renal tissue. "
01/01/1997 - "High tumor-tissue concentrations of dexniguldipine were observed. "
|3.||Lung Neoplasms (Lung Cancer)
01/01/1994 - "In this study, we have tested the hypothesis that dexniguldipine may inhibit the proliferation of lung cancer cells in response to autocrine or exogenous activation of PKC. "
12/01/1991 - "In this study, we have tested the antiproliferative effects of B859-35 and of the Ca(2+)-channel blocker Verapamil in vitro on three human lung cancer cell lines. "
01/01/1994 - "Using a panel of human lung cancer cell lines, we show that dexniguldipine is a potent inhibitor of mitogenic signal transduction pathways dependent on PKC activation in several small-cell and non-small-cell lung cancer cell lines while it failed to inhibit cyclic-AMP-dependent cell proliferation."
01/01/1994 - "Inhibition of protein-kinase-C--dependent cell proliferation of human lung cancer cell lines by the dihydropyridine dexniguldipine."
12/01/1991 - "Antiproliferative effects of the Ca2+/calmodulin antagonist B859-35 and the Ca(2+)-channel blocker verapamil on human lung cancer cell lines."
01/01/1996 - "The chemosensitizing potency of dexniguldipine hydrochloride (B8509-035) on epidoxorubicin was assessed in a multidrug-resistant (MDR) tumour model, the intrinsic MDR rat colon carcinoma CC531. "
01/01/1996 - "Modulation of multidrug resistance with dexniguldipine hydrochloride (B8509-035) in the CC531 rat colon carcinoma model."
11/01/1995 - "These results suggest that the suppression of the growth of HT-29 colon carcinoma cells by DNIG involves the inhibition of the expression of PKC Delta and zeta."
05/01/1996 - "Thus, dexniguldipine-HCl efficiently modulated taxane resistances of the ovarian carcinoma MDR cell line 2780AD in the submicromolar concentration range, whereas cyclosporin A and the other chemosensitizers were rather ineffective. "
11/01/1995 - "Dexniguldipine hydrochloride inhibits growth of human ht-29 colon-carcinoma cells and expression of protein-kinase-C-delta and protein-kinase-C-zeta."
01/26/1998 - "nifedipine, nimodipine, nicardipine, niguldipine, in the neuroblastoma-glioma cell line NG108-15. "
07/18/1997 - "The effects of nifedipine, niguldipine, nimodipine and nitrendipine on the high K+-induced intracellular Ca2+ ([Ca2+]i) transient in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid NG 108-15 cells were studied by using the fluorescent Ca2+ indicator fura-2. "
07/18/1997 - "Consequently, it was demonstrated in the present study that nimodipine and nitrendipine inhibit both L- and N-type calcium channels and thus seem to be unique among the dihydropyridines examined in their effects on calcium channels in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid NG 108-15 cells, whereas nifedipine and niguldipine appear to block mainly L-type calcium channels."
|5.||Anticonvulsants (Antiepileptic Drugs)
|10.||Protein Isoforms (Isoforms)