hemoglobin XL99alpha

formed by the reaction of bis(3,5-dibromosalicyl) fumarate with hemoglobin ; selectively cross-links the alpha subunit between Lys-alpha(1)99 & Lys-alpha(2)99

Also Known As:

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dorman, Scott C: 1 article (01/2002)
2.	Harrington, John P: 1 article (01/2002)
3.	Hirsch, Rhoda Elison: 1 article (01/2002)
4.	Kenny, Clare F: 1 article (01/2002)
5.	Miller, Lee: 1 article (01/2002)

Related Diseases

1.	Hemorrhagic Shock 04/01/1993 - "Human hemoglobin (Hb) and Hb cross-linked between the alpha subunits with bis(3,5-dibromosalicyl)fumarate (alpha alpha Hb) were used to treat hemorrhagic shock in water-deprived swine. " 01/01/1997 - "We hypothesized that the combination of alpha alpha-crosslinked human hemoglobin (alpha alpha Hb), an oxygen carrier and vasoconstrictor, with hypertonic sodium acetate (HAHb), a vasodilator, may be effective for small volume resuscitation of hemorrhagic shock. "
2.	Pulmonary Hypertension 05/01/1997 - "Small-volume infusion of alpha alpha Hb restored mean arterial pressure and brain blood flow, but pulmonary hypertension and low peripheral perfusion may offset benefits for trauma patients." 01/01/1995 - "In swine, HbA0 and alpha alpha Hb caused systemic and pulmonary hypertension and a doubling of the vascular resistance that was equivalent to that seen with inhibition of nitric oxide synthesis. "
3.	Hypertension (High Blood Pressure) 09/01/1993 - "Thus, infusion of alpha alpha Hb caused a transient systemic hypertension, and intramolecular crosslinking alone was not enough to exclude completely the filtration of alpha alpha Hb by the kidneys." 01/01/1995 - "In rabbits HbA0 and human Hb cross-linked with bis(3,5-dibromosalicyl) fumarate (alpha alpha Hb) caused hypertension and pulmonary arteritis. "
4.	Hemorrhage 05/01/1997 - "We tested the hypothesis that the pharmacologic properties of a small volume of alpha alpha-cross-linked hemoglobin (alpha alpha Hb) could effectively resuscitate pigs subjected to hemorrhage. " 09/01/1998 - "We have compared polyethylene glycol-modified bovine hemoglobin (PEG-Hb; high O2 affinity, high viscosity, high oncotic pressure) and human hemoglobin cross-linked between the alpha-chains (alpha alpha-Hb; low O2 affinity, low viscosity, low oncotic pressure) with a non-O2-carrying plasma expander (pentastarch, high viscosity and oncotic pressure) after a 50% (by volume) exchange transfusion followed by a severe (60% of blood volume) hemorrhage. "
5.	Acute Kidney Injury (Acute Renal Failure) 01/01/1995 - "Acute renal failure seen after administration HbA0, did not appear after alpha alpha Hb. "

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Oxygen (Dioxygen)
3.	Sodium Acetate (Sodium Acetate, Anhydrous)
4.	Vasodilator Agents (Vasodilators)
5.	Vasoconstrictor Agents
6.	Polyethylene Glycols (Polyethylene Glycol)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Myoglobin
9.	Hydroxyethyl Starch Derivatives (Pentastarch)
10.	Fumarates

Related Therapies and Procedures

1.	Resuscitation