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HC Blue No. 2

Also Known As:

2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Phenylenediamines: 6
        HC Blue No. 2: 4
  - Aniline Compounds: 46
    - Phenylenediamines: 6
      - HC Blue No. 2: 4

Related Diseases

1.	Carcinogenesis 08/01/1985 - "Toxicology and carcinogenesis studies of HC Blue No. 2 (approximately 98% pure), a semipermanent hair dye, were conducted by administering the test chemical in feed for 103 weeks to groups of 50 F344/N rats of each sex and for 104 weeks to groups of 50 B6C3F 1 mice of each sex. " 08/01/1985 - "NTP Toxicology and Carcinogenesis Studies of HC Blue No. 2 [2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)] (CAS No. 33229-34-4) in F344/N Rats and B6C3F 1 Mice (Feed Studies)." 06/01/1989 - "Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice. "
2.	Lymphoma (Lymphomas) 06/01/1990 - "Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2. III. Effects in the Salmonella typhimurium/Escherichia coli reversion assay and the mouse lymphoma L5178Y TK+/- forward mutation assay." 08/01/1985 - "HC Blue No. 2 was mutagenic in the mouse lymphoma L5178Y/TK+/- assay in the presence of Aroclor 1254-induced male F344/N rat liver S9. "
3.	Chromosome Breakage 06/01/1990 - "Two hair-dye chemicals, HC Blue No. 1 and HC Blue No. 2, were assessed for the ability to produce chromosome breakage and/or spindle malformation in vivo by evaluating the capacity of these compounds to induce micronuclei in polychromatic erythrocytes of mouse bone marrow. "
4.	Hyperostosis 08/01/1985 - "HC Blue No. 2 administration caused a dose-related increase in the incidence of hyperostosis of the skull in male and female rats. "

Related Drugs and Biologics

1.	N- methylamino- 2- nitro- 4- N',N'- bis(2- hydroxyethyl)aminobenzene
2.	Hair Dyes
3.	Phenylenediamines
4.	Ethanol (Ethyl Alcohol)
5.	Aroclors