1-4-(3-methyltriazeno)benzoic acid (MTBA)

structure given in first source

Also Known As:

MTBA; 1-4-(3-methyltriazeno)benzoic acid, monopotassium salt; 1-p-(3-methyltriazeno)benzoic acid potassium salt; 4-(3-methyl-1-triazenyl)benzoic acid; MM-COOK

Networked: 13 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Triazenes: 36
  - 1-4-(3-methyltriazeno)benzoic acid: 13

Experts

1.	Cronin, Michael S: 1 article (01/2018)
2.	Kelly, Niamh: 1 article (01/2018)
3.	McIntyre, Grant T: 1 article (01/2018)
4.	Millett, Declan T: 1 article (01/2018)
5.	Salloum, Erfan: 1 article (01/2018)
6.	Bell, Rachel E: 1 article (08/2015)
7.	Donati, Tommaso: 1 article (08/2015)
8.	Hughes, John: 1 article (08/2015)
9.	Katsanos, Konstantinos: 1 article (08/2015)
10.	Modarai, Bijan: 1 article (08/2015)

Related Diseases

1.	Ototoxicity 05/01/2005 - "In the present study, we aimed at suppressing cisplatin-induced ototoxicity in guinea pigs by administering MTBA or STS perilymphatically through cochlear perfusion. " 10/01/1997 - "It is concluded that the protection conferred by MTBA against cisplatin ototoxicity is associated with sparing of the cochlear antioxidant system." 05/01/2005 - "Systemical co-treatment with anti-oxidants like 4-methylthiobenzoic acid (MTBA) and sodium thiosulfate (STS) provides protection against cisplatin ototoxicity. " 10/01/1997 - "This study was undertaken in order to determine the changes in auditory brainstem-evoked responses relationship with the changes in the levels of GSH, lipid peroxidation and antioxidant enzymes activity in cisplatin-induced ototoxicity and otoprotection by 4-methylthiobenzoic acid (MTBA). "
2.	Melanoma (Melanoma, Malignant) 01/01/1997 - "All melanomas, whether sensitive or resistant to MTBA, were susceptible to anthracycline treatment. " 05/01/1989 - "Treatment of B16/BL6 murine melanoma cells in vitro with the 'xenogenizing' agent potassium p-(3-methyl-1-triazeno)benzoate (MM-COOK) had a profound impact on the tumorigenic and metastatic properties of the tumor, an effect that was only detectable in immunologically intact hosts. " 01/01/1997 - "Both MRD and ADR were tested in vitro on three melanoma lines, MI13443-MEL, SK-MEL-28, and M14, previously screened for their chemosensitivity to the triazene compound p-(3-methyl-1-triazeno) benzoic acid, potassium salt (MTBA). " 01/01/1989 - "The present studies have been conducted on the human cell lines H125 (lung cancer), 1246 (melanoma), X3 (EBV-immortalized B cells) subjected to in vitro treatment with 4 (3-methyl-1-triazeno) benzoic acid potassium salt (MTBA). "
3.	Lung Neoplasms (Lung Cancer) 01/01/1989 - "The present studies have been conducted on the human cell lines H125 (lung cancer), 1246 (melanoma), X3 (EBV-immortalized B cells) subjected to in vitro treatment with 4 (3-methyl-1-triazeno) benzoic acid potassium salt (MTBA). "
4.	Bites and Stings (Sting) 01/01/2018 - "This study aimed to compare the facial soft tissue changes in Caucasians between pre-treatment and with the construction bite versus pre-treatment and completion of treatment with a modified Twin-block appliance (MTBA). " 01/01/2018 - "With MTBA treatment, the soft tissue changes from pre-treatment to with the construction bite in situ, overestimate those from pre- to post-treatment." 01/01/2018 - "The facial soft tissue changes from pre-treatment to with the construction bite were considerably more than those from pre-treatment to completion of treatment with a MTBA. " 01/01/2018 - "Fifty-eight Caucasian subjects with Class II division 1 malocclusion had 3D stereophotogrammetric images captured pre-treatment (T1), with the construction bite (T2), and on completion of MTBA treatment (T3). "
5.	Neoplasms (Cancer) 01/01/1991 - "Unlike DM-COOK, MM-COOK exhibits significant cytotoxicity to metastatic foci and pronounced inhibition of primary tumor development. " 05/01/1989 - "Treatment of B16/BL6 murine melanoma cells in vitro with the 'xenogenizing' agent potassium p-(3-methyl-1-triazeno)benzoate (MM-COOK) had a profound impact on the tumorigenic and metastatic properties of the tumor, an effect that was only detectable in immunologically intact hosts. " 11/01/1987 - "The triazene derivative 1-p-(3-methyltriazeno)benzoic acid potassium salt (MTBA) shows pharmacological properties similar to those of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC, trade name dacarbazine), which is known to induce antigenic modulation in tumor cells (xenogenization) and is currently used in cancer therapy. " 07/01/1988 - "The 1-p-(3-methyltriazeno) benzoic acid potassium salt (MTBA) is a triazeno analogue of dacarbazine, an antineoplastic agent capable of mediating the appearance of new antigenic specificities on cancer cells in mice, a phenomenon described as 'chemical xenogenization' (CX). "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Antioxidants
3.	4-methylthiobenzoic acid
4.	sodium thiosulfate
5.	Potassium
6.	Salts
7.	Benzoic Acid (Potassium Benzoate)
8.	Enzymes
9.	Dacarbazine (DIC)
10.	1-4-(3-methyltriazeno)benzoic acid (MTBA)

Related Therapies and Procedures

1.	Stents
2.	Therapeutics