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perezone

isolated from roots of Pereziae adnata; structure given in Merck Index

Networked: 7 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - perezone: 7

Experts

1.	Hernández-Rodríguez, Maricarmen: 3 articles (02/2022 - 01/2019)
2.	Mendoza Sánchez, Pablo I: 3 articles (02/2022 - 01/2019)
3.	Mera Jiménez, Elvia: 2 articles (02/2022 - 01/2019)
4.	Miranda Ruvalcaba, René: 2 articles (02/2022 - 01/2019)
5.	Rosales Cruz, Erika: 2 articles (02/2022 - 01/2019)
6.	Aceves-Hernández, Juan Manuel: 2 articles (04/2020 - 06/2017)
7.	Nicolás-Vázquez, María Inés: 2 articles (04/2020 - 06/2017)
8.	Maciejewska, Dorota: 1 article (02/2022)
9.	Macías Pérez, Martha E: 1 article (02/2022)
10.	Martínez, Joel: 1 article (02/2022)

Related Diseases

1.	Neoplasms (Cancer) 06/25/2017 - "In silico Study of the Pharmacologic Properties and Cytotoxicity Pathways in Cancer Cells of Various Indolylquinone Analogues of Perezone." 04/01/2020 - "Many natural phyto-products as perezone (Per) exhibit anti-cancer activities. " 06/21/2023 - "Perezone and its phenyl glycine derivative induce cytotoxicity via caspases on human glial cancer cells." 01/01/2019 - "Recently, it was demonstrated that perezone, a sesquiterpene quinone, is capable to induce cell death in leukemia (K562), prostate (PC-3), colorectal (HCT-15) and lung (SKLU-1) cancer cell lines; however, its mechanism of action is unknown. "
2.	Leukemia 07/01/2010 - "In this study, we investigated the cytotoxic effect of perezone, a constituent isolated from the roots of Perezia spp. and of its synthetic isomer isoperezone on the K562 human leukemia cell line. " 01/01/2019 - "Recently, it was demonstrated that perezone, a sesquiterpene quinone, is capable to induce cell death in leukemia (K562), prostate (PC-3), colorectal (HCT-15) and lung (SKLU-1) cancer cell lines; however, its mechanism of action is unknown. "
3.	Glioblastoma (Glioblastoma Multiforme) 02/26/2022 - "In Vitro and Computational Studies of Perezone and Perezone Angelate as Potential Anti-Glioblastoma Multiforme Agents."
4.	Ischemia 01/01/1999 - "In the in vivo rat heart model with transient (5 min) regional ischemia, as induced by left coronary artery ligation, we have demonstrated that perezone reduces dramatically the incidence of reperfusion-induced-arrhythmias. "
5.	Astrocytoma (Pilocytic Astrocytoma) 06/21/2023 - "The new phenyl glycine derivative of perezone was obtained in a single reaction step in ca. 80% yield which showed remarkable cytotoxic activity against the astrocytoma U-251 cell line. "

Related Drugs and Biologics

1.	isoperezone
2.	Caspases
3.	Sesquiterpenes
4.	Glycine (Aminoacetic Acid)
5.	quinone (benzoquinone)

Related Therapies and Procedures

1.	Ligation