HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
4- bromo- 2,7- dimethoxy- 3H- phenothiazin- 3- one
structure given in first source
Also Known As:
L 651.392; L 651392; L-651,392; L-651392
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Phenothiazines: 506
4-bromo-2,7-dimethoxy-3H-phenothiazin-3-one: 4
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Phenothiazines: 506
4-bromo-2,7-dimethoxy-3H-phenothiazin-3-one: 4
Related Diseases
1.
Endotoxemia
09/01/1988 - "
L-651,392 attenuated the alterations in pulmonary hemodynamics, lung mechanics, oxygenation, and lung fluid and solute exchange observed after endotoxemia in sheep.
"
09/01/1988 - "
L-651,392 blocked the increase in LTB4 observed in lung lymph after endotoxemia in vivo in sheep as well as inhibited by 80% the ex vivo production of LTB4 by granulocytes removed from sheep treated 24 h earlier with L-651,392.
"
09/01/1988 - "
Although L-651,392 blocked the increase in cyclooxygenase products of arachidonic acid observed in lung lymph after endotoxemia in vivo in sheep, the drug probably did not function directly as a cyclooxygenase inhibitor.
"
09/01/1988 - "
The efficacy and selectivity of L-651,392 were tested by measuring in vivo production of leukotriene B4 (LTB4) and cyclooxygenase products of arachidonic acid after endotoxemia before and after pretreatment with L-651,392 and ex vivo from granulocytes and whole blood stimulated with calcium ionophore from sheep before and 24 h after pretreatment with L-651,392.
"
2.
Pyelonephritis
07/01/1994 - "
L-651,392, a potent leukotriene inhibitor, controls inflammatory process in Escherichia coli pyelonephritis.
"
07/01/1994 - "
We conclude that L-651,392 prevents inflammatory cells from reaching the site of infection and protects the kidney from tubular damage associated with inflammation during pyelonephritis.
"
07/01/1994 - "
Treatment of infected animals was started 24 h after the induction of pyelonephritis with either hydrocortisone (25 mg/kg of body weight per day), the leukotriene inhibitor L-651,392 (10 mg/kg/day), or the vehicle of L-651,392 and was maintained for 5 days.
"
3.
Inflammation (Inflammations)
07/01/1994 - "
We conclude that L-651,392 prevents inflammatory cells from reaching the site of infection and protects the kidney from tubular damage associated with inflammation during pyelonephritis.
"
4.
Infections
07/01/1994 - "
We conclude that L-651,392 prevents inflammatory cells from reaching the site of infection and protects the kidney from tubular damage associated with inflammation during pyelonephritis.
"
5.
Immediate Hypersensitivity
11/03/1987 - "
The role of leukotrienes as mediators of microvascular permeability changes (assessed through the accumulation of [99mTc]albumin) associated with immediate hypersensitivity reactions in the guinea-pig conjunctiva was investigated by means of two novel, structurally dissimilar 5-lipoxygenase inhibitors, L-651,392 and L-651,896.
"
Related Drugs and Biologics
1.
Lipoxygenase Inhibitors
2.
Leukotrienes
3.
Calcium Ionophores
4.
Cyclooxygenase Inhibitors
5.
Arachidonic Acid (Vitamin F)
6.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7.
Leukotriene B4
8.
Hydrocortisone (Cortisol)
9.
Albumins
10.
leukotriene D4 receptor (cysteinyl leukotriene receptor)