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phelorphan
enkephalinase inhibitor
Also Known As:
2-mercaptoacetyl-L-phenylalanyl-L-phenylalanine; 2-mercaptoacetyl-phenylalanylphenylalanine; L-Phenylalanine, N-(N-(mercaptoacetyl)-L-phenylalanyl)-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
Dipeptides: 945
phelorphan: 2
Related Diseases
1.
Substance Withdrawal Syndrome (Withdrawal Symptoms)
07/01/1987 - "
Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats.
"
07/01/1987 - "
Intracerebroventricular administration of phelorphan (158 nmol/2 microliters), a blocker of dipeptidylaminopeptidase (enkephalinase B) and other enzymes involved in the enkephalin biodegradation, inhibited in chronic morphine-dependent rats, the occurrence of some of the naloxone-precipitated withdrawal symptoms.
"
01/01/1986 - "
Enkephalinase inhibitors phosphoramidon, thiorphan or phelorphan suppressed naloxone-precipitated withdrawal symptoms in acute and chronic morphine dependent mice and rats.
"
2.
Tremor (Tremors)
07/01/1987 - "
In addition, phelorphan compared with the controls or thiorphan, pretreated animals, increased the frequency of paw tremor, head shakes, scratching, erection and ejaculation, but other symptoms were decreased (stretching) or unaltered (teeth chattering).
"
Related Drugs and Biologics
1.
Thiorphan
2.
Naloxone (Narcan)
3.
Morphine (MS Contin)
4.
Neprilysin (Neutral Endopeptidase)
5.
Enzymes
6.
Enkephalins
7.
dipeptidyl peptidase III
8.
phosphoramidon